当前位置: X-MOL 学术Curr. Opin. Insect Sci. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Signal transduction in the early Drosophila follicle stem cell lineage.
Current Opinion in Insect Science ( IF 5.3 ) Pub Date : 2020-01-30 , DOI: 10.1016/j.cois.2019.11.005
Katja Rust 1 , Todd Nystul 1
Affiliation  

The follicle stem cell (FSC) lineage in the Drosophila ovary is a highly informative model of in vivo epithelial stem cell biology. Studies over the past 30 years have identified roles for every major signaling pathway in the early FSC lineage. These pathways regulate a wide variety of cell behaviors, including self-renewal, proliferation, survival and differentiation. Studies of cell signaling in the follicle epithelium have provided new insights into how these cell behaviors are coordinated within an epithelial stem cell lineage and how signaling pathways interact with each other in the native, in vivo context of a living tissue. Here, we review these studies, with a particular focus on how these pathways specify differences between the FSCs and their daughter cells. We also describe common themes that have emerged from these studies, and highlight new research directions that have been made possible by the detailed understanding of the follicle epithelium.



中文翻译:

果蝇早期卵泡干细胞谱系的信号转导。

果蝇卵巢中的卵泡干细胞(FSC)谱系是体内上皮干细胞生物学的高度有用的模型。过去30年的研究已经确定了FSC早期谱系中每个主要信号通路的作用。这些途径调节多种细胞行为,包括自我更新,增殖,存活和分化。卵泡上皮细胞信号转导的研究提供了新的见解,以了解这些细胞行为如何在上皮干细胞谱系内协调,以及信号转导途径如何在天然,体内相互作用活组织的上下文。在这里,我们回顾这些研究,特别关注这些途径如何指定FSC及其子细胞之间的差异。我们还将描述这些研究中出现的共同主题,并强调通过对卵泡上皮细胞的详细了解而使新的研究方向成为可能。

更新日期:2020-01-30
down
wechat
bug