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The regulation of Drosophila ovarian stem cell niches by signaling crosstalk.
Current Opinion in Insect Science ( IF 5.3 ) Pub Date : 2020-01-30 , DOI: 10.1016/j.cois.2019.10.006
Yoshiki Hayashi 1 , Yuto Yoshinari 2 , Satoru Kobayashi 1 , Ryusuke Niwa 1
Affiliation  

The Drosophila female ovary is an excellent model for investigating how multiple stem cell types are coordinately regulated in vivo. The ovary contains at least two stem cell types, germline stem cells (GSCs) and somatic follicular stem cells (FSCs). Although GSCs and FSCs are maintained within a distinct extra-cellular microenvironment, known as a niche, they share some common signaling molecules to generate their own niche. To properly maintain these stem cell types, understanding how signaling molecules are regulated is essential. In this review, we summarize the recent understanding of the mechanisms maintaining GSCs and FSCs from the perspective of growth factor regulation and discuss how these regulatory mechanisms contribute to stem cell maintenance, competition, and survival.



中文翻译:

果蝇卵巢干细胞壁signaling的信号传导调控。

果蝇女性卵巢是研究如何多的干细胞类型的协同调控一个很好的模式在体内。卵巢包含至少两种干细胞类型,种系干细胞(GSC)和体细胞滤泡干细胞(FSC)。尽管GSC和FSC维持在独特的细胞外微环境(称为小生境)中,但它们共享一些常见的信号分子来生成自己的小生境。为了适当地维持这些干细胞类型,了解信号分子是如何调控的至关重要。在这篇综述中,我们从生长因子调控的角度总结了对维持GSC和FSC维持机制的最新理解,并讨论了这些调控机制如何促进干细胞的维持,竞争和存活。

更新日期:2020-01-30
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