BACKGROUND Previous individual studies have shown the differences in inflammatory cytokines and gray matter volumes between bipolar disorder (BD) and unipolar depression (UD). However, few studies have investigated the association between pro-inflammatory cytokines and differences in brain gray matter volumes between BD and UD. METHODS In this study, 72 BD patients and 64 UD patients were enrolled, with comparable gender and age distributions (33.8% males and an average age of 39.3 ± 13.7 years). Each participant underwent metabolic profiling (including body mass index (BMI), glucose, triglyceride, high-density lipoprotein (HDL), leptin, insulin, adiponectin), pro-inflammatory cytokine (including soluble interleukin-6 receptor (sIL-6R), soluble interleukin-2 receptor (sIL-2R), C-reactive protein (CRP), soluble tumor necrosis factor receptor type 1 (sTNF-R1) examinations, and structural magnetic resonance imaging exams. Voxel-based morphometry was performed to investigate the gray matter volume differences between BD and UD patients. Correlations between pro-inflammatory cytokines and the gray matter volume difference were analyzed. RESULTS Compared to UD patients, the BD group had significantly higher BMI, and higher levels of sIL-6R and sTNF-R1 than the UD patients. The BMI significantly correlated with the level of pro-inflammatory cytokines. Adjusted for age, sex, BMI, duration of illness and total intracranial volume, the BD individuals had significantly more reduced gray matter volumes over 12 areas: R. cerebellar lobule VIII, R. putamen, L. putamen, R. superior frontal gyrus, L. lingual gyrus, L. precentral gyrus, R. fusiform gyrus, L. calcarine, R. precuneus, L. inferior temporal gyrus, L. hippocampus, and L. superior frontal gyrus. These 12 gray matter volume differences between BP and UD patients negatively correlated with sIL-6R and sTNF-R1 levels. CONCLUSIONS Our results suggested that BD patients had higher BMI and pro-inflammatory cytokine levels in comparison to UD patients, especially IL-6 and sTNF-R1, which may contribute to greater gray matter reductions in BD patients in comparison to UD patients. The results support the neuro-inflammation pathophysiology mechanism in mood disorder. It is clinically important to monitor BMI, which, in this investigation, positively correlated with levels of inflammatory cytokines.

中文翻译：

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躁郁症和抑郁症患者的代谢谱，免疫力和脑灰质体积的比较研究。

背景技术以前的个人研究表明，双相情感障碍（BD）和单相抑郁（UD）之间炎症细胞因子和灰质体积的差异。但是，很少有研究调查促炎性细胞因子与BD和UD之间脑灰质体积差异之间的关系。方法在该研究中，纳入了72例BD患者和64例UD患者，其性别和年龄分布相当（男性33.8％，平均年龄39.3±13.7岁）。每位参与者都进行了代谢分析（包括体重指数（BMI），葡萄糖，甘油三酸酯，高密度脂蛋白（HDL），瘦素，胰岛素，脂联素），促炎性细胞因子（包括可溶性白介素6受体（sIL-6R），可溶性白介素2受体（sIL-2R），C反应蛋白（CRP），可溶性肿瘤坏死因子受体1型（sTNF-R1）检查和结构磁共振成像检查。进行基于体素的形态计量学以研究BD和UD患者之间的灰质体积差异。分析了促炎细胞因子与灰质体积差异之间的相关性。结果与UD患者相比，BD组的BMI显着高于UD患者，而sIL-6R和sTNF-R1水平也明显高于UD患者。BMI与促炎细胞因子水平显着相关。经过年龄，性别，BMI，疾病持续时间和颅内总体积的调整后，BD个体在以下12个区域的灰质体积显着降低：小脑小叶VIII，普塔门R. Putamen，普塔门R.额额回， L.舌舌回，L。前中央回，R。梭状回，L。钙car碱，早产儿螺，下颞叶回，海马L和上额叶回。BP和UD患者之间的这12个灰质体积差异与sIL-6R和sTNF-R1水平负相关。结论我们的结果表明，与UD患者相比，BD患者的BMI和促炎细胞因子水平更高，尤其是IL-6和sTNF-R1，与UD患者相比，这可能有助于BD患者更大程度地减少灰质。结果支持情绪障碍的神经炎症病理生理机制。监测BMI在临床上很重要，在这项研究中，BMI与炎症细胞因子的水平呈正相关。BP和UD患者之间的这12个灰质体积差异与sIL-6R和sTNF-R1水平负相关。结论我们的结果表明，与UD患者相比，BD患者的BMI和促炎细胞因子水平更高，尤其是IL-6和sTNF-R1，与UD患者相比，这可能有助于BD患者更大程度地减少灰质。结果支持情绪障碍的神经炎症病理生理机制。监测BMI在临床上很重要，在这项研究中，BMI与炎症细胞因子的水平呈正相关。BP和UD患者之间的这12个灰质体积差异与sIL-6R和sTNF-R1水平呈负相关。结论我们的结果表明，与UD患者相比，BD患者的BMI和促炎细胞因子水平更高，尤其是IL-6和sTNF-R1，与UD患者相比，这可能有助于BD患者更大程度地减少灰质。结果支持情绪障碍的神经炎症病理生理机制。监测BMI在临床上很重要，在这项研究中，BMI与炎症细胞因子的水平呈正相关。与UD患者相比，这可能有助于BD患者减少更多的灰质。结果支持情绪障碍的神经炎症病理生理机制。监测BMI在临床上很重要，在这项研究中，BMI与炎症细胞因子的水平呈正相关。与UD患者相比，这可能有助于BD患者减少更多的灰质。结果支持情绪障碍的神经炎症病理生理机制。监测BMI在临床上很重要，在这项研究中，BMI与炎症细胞因子的水平呈正相关。