Overt Cushing's syndrome is a severe condition responsible for multiple comorbidities and increased mortality. Effective treatment is essential to reduce mortality, improve comorbidities and long-term quality of life. Surgical resection of the causal lesion(s) is generally the first-line and most effective treatment to normalize cortisol secretion. Adjunctive symptomatic treatments of co-morbidities are often necessary both during the active phase of the disease and for persisting co-morbidities after cessation of hypercortisolism. Second-line treatments include various pharmacological treatments, bilateral adrenalectomy, and radiotherapy of corticotroph tumors. The choice of these treatments is complex, must be performed in a multidisciplinary expert team to be individualized for each patient, and use a shared decision-making approach.

库欣氏综合症是一种导致多种合并症和增加死亡率的严重疾病。有效的治疗对于降低死亡率，改善合并症和长期生活质量至关重要。通常，对因果病变进行手术切除是使皮质醇分泌正常化的第一线也是最有效的治疗方法。对合并症的辅助对症治疗常常是必需的，无论是在疾病的活跃期，还是在停止高皮质醇血症后持续合并症。二线治疗包括各种药物治疗，双侧肾上腺切除术和皮质激素肿瘤的放射治疗。这些治疗方法的选择很复杂，必须在一个多学科的专家团队中进行以针对每个患者进行个性化，并使用一种共享的决策方法。