Environmental Enrichment leads to a significant improvement in long-term performance across a range of cognitive functions in mammals and it has been shown to produce an increased synaptic density and neurogenesis. Nevertheless it is still an open question as to whether some key aspects of spatial learning & memory and procedural learning might be embodied by different molecular pathways to those of social cognition. Associated with synaptic changes and potentially underlying conditions, the Ras-ERK pathway has been proposed to be the primary mediator of in vivo adaptations to environmental enrichment, acting via the downstream Ras-ERK signalling kinase MSK1 and the transcription factor CREB. Herein, we show that valence of environmental stimulation increased social competition and that this is associated with a specific proteomic signature in the frontal lobe but notably not in the hippocampus. Specifically, we show that altering the valence of environmental stimuli affected the level of social competition, with mice from negatively enriched environments winning significantly more encounters-even though mice from positive were bigger and should display dominance. This behavioural phenotype was accompanied by changes in the proteome of the fronto-ventral pole of the brain, with a differential increase in the relative abundance of proteins involved in the mitochondrial metabolic processes of the TCA cycle and respiratory processes. Investigation of this proteomic signature may pave the way for the elucidation of novel pathways underpinning the behavioural changes caused by negative enrichment and further out understanding of conditions whose core feature is increased social competition.

中文翻译：

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中枢神经系统适应环境刺激价的蛋白质组学特征。

在哺乳动物的一系列认知功能中，环境富集导致长期性能的显着改善，并且已经证明，环境富集会产生增加的突触密度和神经发生。然而，关于空间学习与记忆以及程序学习的某些关键方面是否可以通过通往社会认知的不同分子途径来体现，仍然是一个悬而未决的问题。Ras-ERK通路与突触的变化和潜在的潜在条件相关联，被认为是通过下游Ras-ERK信号激酶MSK1和转录因子CREB起作用的体内适应环境富集的主要介质。在这里 我们表明环境刺激的价会增加社会竞争，这与额叶中的特定蛋白质组学特征有关，但在海马中却没有。具体而言，我们表明，改变环境刺激的效价会影响社会竞争的水平，来自负向富集环境的小鼠会赢得更多的遭遇，即使来自正向的小鼠较大且应显示出优势。这种行为表型伴随着大脑额腹极蛋白质组的变化，参与TCA周期的线粒体代谢过程和呼吸过程的蛋白质相对丰度也有所不同。