PURPOSE Obesity has emerged as one of the biggest health crisis and is the leading cause of death and disabilities around the world. BMI trends suggest that majority of the increase in T2D is resulting from the increased prevalence of obesity. In fact, 85.2% of people with T2D are overweight or obese. The highest prevalence for obesity is seen in non-Hispanic, African American women (56.6%). T2D is classified as an inflammatory disease because of elevated, circulating pro-inflammatory cytokines and acute-phase inflammatory proteins. This study was designed to determine how high HbA1c and serum glucose correlate with circulatory cytokine levels in obese, African American women. METHODS We investigated cytokine/chemokine serum levels using a multiplex assay. Then we used Pairwise Pearson Correlation Test to determine the relationship between clinical metabolic parameters and cytokine/chemokine serum levels. RESULTS The results indicated that participants with elevated HbA1c exhibited an up regulation of IL-3, IL-4, IL-7, TNF-α, IFN-α2 and CX3CL1 serum levels compared to participants with normal HbA1c. These cytokines were also correlated with several clinical metabolic parameters. CONCLUSIONS The results suggest that IL-3, IL-4, IL-7, TNF-α, IFN-α2 and CX3CL1 serum levels may contribute to the development and onset of type 2 diabetes.

中文翻译：

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肥胖和 HbA1c 升高的非裔美国女性的循环细胞因子水平增加

目的 肥胖已成为最大的健康危机之一，并且是全世界死亡和残疾的主要原因。BMI 趋势表明，T2D 增加的大部分原因是肥胖患病率的增加。事实上，85.2% 的 T2D 患者超重或肥胖。非西班牙裔、非裔美国女性的肥胖患病率最高（56.6%）。由于升高的循环促炎细胞因子和急性期炎症蛋白，T2D 被归类为炎性疾病。本研究旨在确定高 HbA1c 和血清葡萄糖与肥胖的非裔美国女性的循环细胞因子水平之间的相关性。方法我们使用多重分析研究了细胞因子/趋化因子血清水平。然后我们使用 Pairwise Pearson Correlation Test 来确定临床代谢参数与细胞因子/趋化因子血清水平之间的关系。结果 结果表明，与 HbA1c 正常的参与者相比，HbA1c 升高的参与者表现出 IL-3、IL-4、IL-7、TNF-α、IFN-α2 和 CX3CL1 血清水平的上调。这些细胞因子也与几个临床代谢参数相关。结论 结果表明，IL-3、IL-4、IL-7、TNF-α、IFN-α2 和 CX3CL1 血清水平可能有助于 2 型糖尿病的发生和发作。这些细胞因子也与几个临床代谢参数相关。结论 结果表明，IL-3、IL-4、IL-7、TNF-α、IFN-α2 和 CX3CL1 血清水平可能有助于 2 型糖尿病的发生和发作。这些细胞因子也与几个临床代谢参数相关。结论 结果表明，IL-3、IL-4、IL-7、TNF-α、IFN-α2 和 CX3CL1 血清水平可能有助于 2 型糖尿病的发生和发作。