Objective

To evaluate the association between potential exposure to different pollen concentrations at the 11th fetal week and subsequent clinical atopic diseases.

Study design and setting

Parents of 1- to 4-year-old children (N = 3035) returned a questionnaire regarding physician-diagnosed atopic diseases. The children were born between 2001 and 2005 in the province of South Karelia, Finland. Results of allergy tests were collected from patient records in the area.

Results

The prevalence of atopic diseases with sensitisation was higher in children whose 11th fetal week occurred during pollen rather than non-pollen season: atopic eczema 6.3% vs. 4.3% (adjusted odds ratio, aOR 1.58, 95% CI 1.10─2.28), food allergy 5.7% vs. 3.9% (1.63; 1.12─2.38), respiratory allergy or asthma 3.7% vs. 2.2% (2.03; 1.24─3.33) and any atopic diseases 7.4% vs. 5.5% (1.48; 1.07─2.05), respectively. Respectively, the prevalence was higher in the children exposed to high rather than low tree pollen concentrations (>1000 vs. <10 particles/m³) at the 11th fetal week: 12.1% vs. 4.4% (3.35; 1.89─5.95), 12.1% vs. 3.9% (3.77; 2.11─6.72), 4.7% vs. 2.5% (2.95; 1.21─7.20) and 14.0% vs. 5.7% (3.15; 1.86─5.35).

Conclusion

Coincidence of potential exposure to high tree pollen concentrations at the 11th fetal week is associated with subsequent clinical atopic diseases with sensitisation.

中文翻译：

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芬兰一项基于人口的研究表明，在头三个月末花粉季节的出现可预测后代的临床特应性疾病。

目的

为了评估在胎儿第11周可能接触不同花粉浓度的潜在风险与随后的临床特应性疾病之间的关联。

研究设计和设置

1至4岁儿童的父母（N = 3035）返回了有关医生诊断的特应性疾病的问卷。这些孩子在2001年至2005年之间出生于芬兰的南卡累利阿省。从该地区的患者记录中收集了过敏测试的结果。

结果

在花粉期而非非花粉季节发生的第11个胎儿周的儿童中，致敏性过敏性疾病的患病率更高：特应性湿疹6.3％vs. 4.3％（校正后的优势比，aOR 1.58，95％CI1.10─2.28），食物过敏5.7％对3.9％（1.63;1.12─2.38），呼吸道过敏或哮喘3.7％对2.2％（2.03;1.24─3.33）和任何特应性疾病7.4％对5.5％（1.48;1.07─2.05），分别。分别在第11个胎儿周时，花粉浓度高而不是低的儿童（> 1000比<10个颗粒/ m ³）的患病率更高：分别为12.1％和4.4％（3.35； 1.89‑5.95）， 12.1％对3.9％（3.77;2.11─6.72），4.7％对2.5％（2.95;1.21─7.20）和14.0％对5.7％（3.15;1.86─5.35）。

结论

胎儿第11周潜在接触高树花粉浓度的巧合与随后的过敏性临床特应性疾病有关。