The skin plays a key role in vector-borne diseases because it is the site where the arthropod coinoculates pathogens and its saliva. Lyme borreliosis, particularly well investigated in this context, is a multisystemic infectious disease caused by Borrelia burgdorferi sensu lato and transmitted by the hard tick Ixodes. Numerous in vitro studies were conducted to better understand the role of specific skin cells and tick saliva in host defense, vector feeding, and pathogen transmission. The skin was also evidenced in various animal models as the site of bacterial multiplication and persistence. We present the achievements in this field as well as the gaps that impede comprehensive knowledge of the disease pathophysiology and the development of efficient diagnostic tools and vaccines in humans.

中文翻译：

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皮肤界面，莱姆疏螺旋体中疏螺旋体繁殖和持久性的关键因素。

皮肤在媒介传播的疾病中起关键作用，因为它是节肢动物共接种病原体及其唾液的部位。莱姆病borreliosis是一种多系统传染病，由伯氏疏螺旋体引起，由硬tick虱传播。进行了许多体外研究，以更好地了解特定皮肤细胞和tick唾液在宿主防御，载体摄食和病原体传播中的作用。在各种动物模型中还证明了皮肤是细菌繁殖和持久性的部位。我们介绍了该领域的成就以及阻碍全面了解疾病病理生理学以及开发有效的人类诊断工具和疫苗的差距。