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The Pharmacopea within Triatomine Salivary Glands.
Trends in Parasitology ( IF 9.6 ) Pub Date : 2020-01-29 , DOI: 10.1016/j.pt.2019.12.014
Paula B Santiago 1 , Carla N de Araújo 1 , Sébastien Charneau 2 , Yanna R Praça 1 , Izabela M D Bastos 1 , José M C Ribeiro 3 , Jaime M Santana 1
Affiliation  

Triatomines are blood-feeding insects that prey on vertebrate hosts. Their saliva is largely responsible for their feeding success. The triatomine salivary content has been studied over the past decades, revealing multifunctional bioactive proteins targeting the host´s hemostasis and immune system. Recently, sequencing of salivary-gland mRNA libraries revealed increasingly complex and complete transcript databases that have been used to validate the expression of deduced proteins through proteomics. This review provides an insight into the journey of discovery and characterization of novel molecules in triatomine saliva.

中文翻译:

Triatomine唾液腺中的Pharmacopea。

Triatomines是摄食脊椎动物宿主的食血昆虫。他们的唾液在很大程度上决定了他们的喂养成功。在过去的几十年中,对三松碱唾液的含量进行了研究,揭示了针对宿主止血和免疫系统的多功能生物活性蛋白。最近,唾液腺mRNA文库的测序揭示了越来越复杂和完整的转录本数据库,这些数据库已用于通过蛋白质组学验证推论蛋白质的表达。这篇综述提供了对三atomine唾液中新分子发现和表征过程的见解。
更新日期:2020-01-29
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