Humans are constantly exposed to fungi, either in the form of commensals at epithelial barriers or as inhaled spores. Innate immune cells play a pivotal role in maintaining commensal relationships and preventing skin, mucosal, or systemic fungal infections due to the expression of pattern recognition receptors that recognize fungal cell wall components and modulate both their activation status and the ensuing adaptive immune response. Commensal fungi also play a critical role in the modulation of homeostasis and disease susceptibility at epithelial barriers. This review will outline cellular and molecular mechanisms of anti-fungal innate immunity focusing on C-type lectin receptors and their relevance in the context of host-fungi interactions at skin and mucosal surfaces in murine experimental models as well as patients susceptible to fungal infections.

中文翻译：

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上皮屏障抗真菌先天免疫的细胞和分子机制：C型凝集素受体的作用。

人类经常接触真菌，无论是上皮屏障处的共生体还是吸入的孢子。先天免疫细胞在维持共生关系和预防皮肤、粘膜或全身真菌感染方面发挥着关键作用，因为它表达模式识别受体，识别真菌细胞壁成分并调节其激活状态和随后的适应性免疫反应。共生真菌在调节上皮屏障的稳态和疾病易感性方面也发挥着关键作用。本综述将概述抗真菌先天免疫的细胞和分子机制，重点关注 C 型凝集素受体及其在小鼠实验模型以及易受真菌感染的患者皮肤和粘膜表面宿主真菌相互作用背景下的相关性。