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Nicotine delivery and users’ reactions to Juul compared with cigarettes and other e‐cigarette products
Addiction ( IF 6 ) Pub Date : 2020-01-29 , DOI: 10.1111/add.14936
Peter Hajek 1 , Kate Pittaccio 1 , Francesca Pesola 2 , Katie Myers Smith 1 , Anna Phillips-Waller 1 , Dunja Przulj 1
Affiliation  

Abstract Aims To assess the pharmacokinetic (PK) profile of, and users’ reactions to, Juul (59 mg nicotine/ml) as an indication of its therapeutic and dependence potential. Design Cross‐over, within‐subjects study in which participants attended after overnight abstinence on separate sessions and smoked a cigarette or used Juul or eight other types of e‐cigarettes (EC) ad libitum for 5 minutes. The Juul product used was the version available in the United States that has more nicotine in the e‐liquid than the one available in the European Union. Setting Laboratory setting in the United Kingdom. Participants Twenty dual users (smokers who also vape) provided data on Juul and cigarettes, with eight also providing data on other EC products. Measurements At each session, number of puffs taken was counted during the 5‐minute product use period and blood samples were taken at baseline and at 2, 4, 6, 8, 10 and 30 minutes after starting smoking/vaping and analysed for nicotine. Participants also monitored their urges to smoke and rated the products on a range of characteristics. Findings Juul's PK profile was close to the PK profile of cigarettes [maximum concentration (Cmax) = 20.4 versus 19.2 ng/ml; time to maximum concentration (Tmax) = 4 versus 6 minutes; area under the curve (AUC): 307.9 versus 312.6, respectively]. Compared with other EC products, Juul had shorter Tmax [4 minutes, (IQR = 2.5–4.0) versus 6.3 minutes, (IQR = 4.7 – 8.1), P = 0.012] and higher Cmax (28.9 (SD = 15.6) versus 10.6 (SD = 5.5), P = 0.013) despite a lower number of puffs (12.5 (SD = 4.2) versus 17.0 (SD = 4.2), P = 0.084). Compared with other e‐cigarette products, it also provided faster reduction of urges to smoke and obtained more favourable subjective ratings. Conclusion Juul's PK profile and user ratings suggest that it could be more effective than other EC products in helping smokers to quit smoking, but it may also have a higher potential to generate regular use in non‐smokers.

中文翻译:

与香烟和其他电子烟产品相比,尼古丁传递和用户对 Juul 的反应

摘要 目的 评估 Juul(59 毫克尼古丁/毫升)的药代动力学 (PK) 特征和使用者对 Juul(59 毫克尼古丁/毫升)的反应,作为其治疗和依赖性潜力的指标。设计交叉、受试者内研究,参与者在隔夜禁欲后参加单独的会议并抽一支烟或随意使用 Juul 或其他八种类型的电子烟 (EC) 5 分钟。使用的 Juul 产品是美国的版本,其电子烟油中的尼古丁含量高于欧盟的产品。设置 英国的实验室设置。参与者 20 名双重用户(也吸电子烟的吸烟者)提供了有关 Juul 和香烟的数据,其中 8 名还提供了其他 EC 产品的数据。测量 在每个会话中,在 5 分钟的产品使用期间计算抽吸次数,并在基线和开始吸烟/抽电子烟后 2、4、6、8、10 和 30 分钟采集血样,并分析尼古丁。参与者还监测他们的吸烟冲动并根据一系列特征对产品进行评级。结果 Juul 的 PK 曲线接近于香烟的 PK 曲线[最大浓度 (Cmax) = 20.4 与 19.2 ng/ml;达到最大浓度的时间 (Tmax) = 4 对 6 分钟;曲线下面积 (AUC):分别为 307.9 和 312.6]。与其他 EC 产品相比,Juul 的 Tmax [4 分钟,(IQR = 2.5–4.0) 比 6.3 分钟,(IQR = 4.7 – 8.1),P = 0.012] 更短,Cmax (28.9 (SD = 15.6) 比 10.6 ( SD = 5.5),P = 0.013),尽管抽吸次数较少(12.5(SD = 4.2)与 17.0(SD = 4.2),P = 0.084)。与其他电子烟产品相比,它还提供了更快的减少吸烟冲动并获得更有利的主观评价。结论 Juul 的 PK 资料和用户评分表明,它在帮助吸烟者戒烟方面可能比其他 EC 产品更有效,但它也可能有更高的潜力让非吸烟者经常使用。
更新日期:2020-01-29
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