Orthohantaviruses are negative-sense, single-stranded RNA viruses harbored by rodents, shrews, moles, and bats. Of the shrew-borne orthohantaviruses in the Republic of Korea (ROK), Jeju orthohantavirus (Jeju virus, JJUV) was found on Jeju Island. This small-scale epidemiologic survey investigated the geographic distribution and molecular phylogeny of JJUV in the ROK. In 32 trapping sites, tissues of 84 Crocidura shantungensis were analyzed for JJUV RNA. JJUV RNA was detected in seven (8.3%) shrews captured on the Korean peninsula. The molecular epidemiologic survey demonstrated the prevalence of JJUV by geographic distribution. The RNA loads of JJUV were evaluated in various tissues. Entire coding sequences of tripartite genomes were recovered from two JJUV strains on the mainland. Phylogenetic relationships of the JJUV revealed a distinct geographic lineage of mainland strains from the strains on Jeju Island. This study sheds light on the molecular epidemiology, phylogeographic diversity, and virus-host co-divergence of JJUV, ROK.

中文翻译：

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大韩民国济州支原体病毒（Hantaviridae）的遗传多样性和种系。

原始汉坦病毒是由啮齿动物，sh，mole鼠和蝙蝠所藏的负义单链RNA病毒。在大韩民国（ROK）的sh传播的正汉坦病毒中，在济州岛上发现了济州正汉坦病毒（济州病毒，JJUV）。这项小型流行病学调查调查了韩国JJUV的地理分布和分子系统发育。在32个诱捕位点中，分析了84个山东汕头金眼鳄组织的JJUV RNA。在朝鲜半岛捕获的七只sh中检测到JJUV RNA。分子流行病学调查通过地理分布证明了JJUV的流行。在各种组织中评估了JJUV的RNA含量。从大陆上的两个JJUV菌株中回收了三方基因组的整个编码序列。JJUV的系统发生关系揭示了与济州岛上的菌株不同的大陆菌株地理谱系。这项研究揭示了韩国JJUV的分子流行病学，系统地理学多样性和病毒-宿主共分化。