It is well-known that aldehydes resulting from the in vivo oxidation of primary alcohols are toxic. Here, we experimentally demonstrate in rat models that the dipeptide cysteinylglycine (CG), formed in vivo from its oxidized product, cystinyl-bis-glycine (CbG), will sequester acetaldehyde and isoamyl aldehyde, two model aldehydes resulting from the oxidation of ethanol and isoamyl alcohol, respectively, and excrete them in urine as their respective conjugation products with CG. These data suggest that a whole series of toxic aldehydes can be sequestered and detoxified by CG and may prevent the flushing syndrome exhibited by individuals with a defective enzyme that converts acetaldehyde to acetate. The data also suggest the possibility of alleviating the hangover syndrome we believe to be caused by aldehydes, such as isoamyl aldehyde derived from short, branched-chain alcohols, present as congeners in certain alcoholic beverages. The sequestration of other toxic agents, such as cyanide, that can react with CG can also be envisioned.

中文翻译：

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隔离和消除有毒的醛。

众所周知，由伯醇的体内氧化产生的醛是有毒的。在这里，我们通过实验证明在大鼠模型中，由其氧化产物半胱氨酰双甘氨酸（CbG）体内形成的二肽半胱氨酸甘氨酸（CG）将螯合乙醛和异戊醛，这两种乙醛是乙醇和乙醇氧化产生的模型醛异戊醇分别作为尿素与CG的结合产物排泄在尿中。这些数据表明，CG可以隔离和去除一系列有毒的醛，并且可以防止具有缺陷的酶（将乙醛转化为乙酸盐）的个体所表现出的潮红综合症。数据还表明，有可能缓解我们认为是由醛引起的宿醉综合征，如衍生自短支链醇的异戊醛，在某些酒精饮料中以同源物形式存在。也可以设想将可能与CG反应的其他有毒物质螯合，例如氰化物。