Developing technologies that allow the simultaneous diagnosis and treatment of cancer (theragnostic) has been the quest of numerous interdisciplinary research teams. In this context, nanomaterials incorporating prototypic near infrared (NIR)-light responsive heptamethine cyanines have been showing very promising results for cancer theragnostic. The precisely engineered features of these nanomaterials endow them with the ability to achieve a high tumor accumulation, enabling a tumor's visualization by NIR fluorescence and photoacoustic imaging modalities. Upon interaction with NIR light, the tumor-homed heptamethine cyanine-incorporating nanomaterials can also produce a photothermal/photodynamic effect with a high spatio-temporal resolution and minimal side effects, leading to an improved therapeutic outcome. This progress report analyses the application of nanomaterials incorporating prototypic NIR-light responsive heptamethine cyanines (IR775, IR780, IR783, IR797, IR806, IR808, IR820, IR825, IRDye 800CW, and Cypate) for cancer photothermal therapy, photodynamic therapy, and imaging. Overall, the continuous development of nanomaterials incorporating the prototypic NIR absorbing heptamethine cyanines will cement their phototheragnostic capabilities.

中文翻译：

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原型七甲基花青素掺入纳米材料的癌症光疗法。

开发能够同时诊断和治疗癌症（鼻窦炎）的技术一直是众多跨学科研究团队的追求。在这种情况下，掺入原型近红外（NIR）-光响应性七甲胺花菁的纳米材料已经显示出对癌症治疗有非常有希望的结果。这些纳米材料的精确设计特征使其具有实现高肿瘤积累的能力，从而可以通过NIR荧光和光声成像方式将肿瘤可视化。在与近红外光相互作用时，掺有肿瘤的七甲基亚甲基花青的纳米材料还可以产生具有高时空分辨率和最小副作用的光热/光动力效应，从而改善治疗效果。该进展报告分析了包含原型近红外光响应性七甲胺花菁（IR775，IR780，IR783，IR797，IR806，IR808，IR820，IR825，IRDye 800CW和Cypate）的纳米材料在癌症光热疗法，光动力疗法和成像中的应用。总体而言，结合原型NIR吸收七甲胺花菁的纳米材料的不断发展将巩固其光热疗能力。