Exposure to VOCs is linked to health effects ranging from asthma to cancer and to negative impacts on the hematopoietic system. We examined the association between select blood VOC concentrations and hematological measures in a representative sample of the U.S. population from NHANES cycles spanning the years 2005 to 2010. We used Cox regression to assess the association between complete blood count with five-part differential (CBC) parameters and seven select blood VOCs, while addressing low detection rates among VOCs. Tobacco smoke exposure was classified using serum cotinine levels. The not-smoke-exposed group had lower VOC levels for most analytes compared with the smoke-exposed. Correlations between benzene, toluene, ethylbenzene, and xylenes (BTEX) were moderate to strong. Statistical associations were found between benzene, toluene, ethylbenzene, xylene, and styrene (BTEXS) and hematocrit, hemoglobin, and white blood cell count among the smoke-exposed. Among the not-smoke-exposed, there was an association between BTEX and platelet count. We considered benzene most likely to be associated with higher levels of CBC concentrations. Our findings suggest VOC levels currently found in the general U.S. population are associated with changes in hematological measures, and smoking could be a contributor.

中文翻译：

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NHANES 2005-2010 中选定血液 VOC 与血液学指标之间的关联。

接触 VOC 与从哮喘到癌症等健康影响以及对造血系统的负面影响有关。我们从 2005 年到 2010 年的 NHANES 周期中检查了美国人口代表性样本中特定血液 VOC 浓度与血液学指标之间的关联。我们使用 Cox 回归来评估全血细胞计数与五部分差分 (CBC) 之间的关联参数和七个选择血液 VOC，同时解决 VOC 中的低检测率问题。使用血清可替宁水平对烟草烟雾暴露进行分类。与烟雾暴露组相比，未暴露于烟雾组的大多数分析物的 VOC 水平较低。苯、甲苯、乙苯和二甲苯 (BTEX) 之间的相关性从中等到强。在苯、甲苯、暴露在烟雾中的乙苯、二甲苯和苯乙烯 (BTEXS) 以及血细胞比容、血红蛋白和白细胞计数。在未接触烟雾的人群中，BTEX 与血小板计数之间存在关联。我们认为苯最有可能与较高水平的 CBC 浓度有关。我们的研究结果表明，目前在美国普通人群中发现的 VOC 水平与血液学指标的变化有关，吸烟可能是一个因素。