The Cover Feature shows the novel hybrid of phenylsulfonylfuroxan and estradiol derivative 11b exhibited the best activity with IC₅₀ values of 3.58‐0.0008 μm against the MDA‐MB‐231, A2780 and Hela cell lines. NO‐releasing capacity and inhibition of ERK/MAPK pathway signaling might explain the potent antineoplastic activity of 11b. Preliminary pharmacological studies showed that 11b induced apoptosis and hardly affected the cell cycle of MDA‐MB‐231 cell line. More information can be found in the Full Paper by Qui Wan et al. on page 176 in Issue 2, 2020 (DOI: 10.1002/open.201900228).

中文翻译：

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封面人物：苯磺酰呋喃喃和雌二醇衍生物的新型杂合物的合成和抗肿瘤评价（ChemistryOpen 2/2020）

封面功能显示phenylsulfonylfuroxan和雌二醇衍生物的新颖的混合11B表现出最佳活性，IC _50个的3.58-0.0008μ值米针对MDA-MB-231，A2780和Hela细胞系。NO释放能力和对ERK / MAPK途径信号的抑制可能解释了11b的强抗肿瘤活性。初步药理研究表明，11b诱导细胞凋亡，几乎不影响MDA-MB-231细胞系的细胞周期。更多信息可以在Qui Wan等人的“全文”中找到。关于在第2期176页，2020（DOI：10.1002 / open.201900228）。