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Effects of different polyaniline emeraldine compositions in electrodepositing ginsenoside encapsulated poly(lactic-co-glycolic acid) microcapsules coating: Physicochemical characterization and in vitro evaluation.
Journal of Biomedical Materials Research Part A ( IF 4.9 ) Pub Date : 2020-02-04 , DOI: 10.1002/jbm.a.36891
Siti Khadijah Lukman 1 , Syafiqah Saidin 1, 2
Affiliation  

Even though drug‐eluting stent (DES) has prominently reduced restenosis, however, its complication of delayed endothelialization has caused chronic side effect. A coating of ginseng‐based biodegradable polymer could address this issue due to its specific therapeutic values. However, deposition of this type of stable coating on metallic implant often scarce. Therefore, in this study, different polyaniline (PANI) emeraldine compositions were adopted to electrodeposit ginsenoside encapsulated poly(lactic‐co‐glycolic acid) microcapsules coating. The coating surfaces were analyzed using attenuated total reflectance‐Fourier transform infrared spectroscopy, X‐ray photoelectron spectroscopy, scanning electron microscopy, contact angle, and atomic force microscopy instruments. A month coating stability was then investigated with an evaluation of in vitro human umbilical vein endothelial cell analyses consisted of cytotoxicity and cells attachment assessments. The 1.5 mg PANI emeraldine has assisted the formation of stable, uniform, and rounded microcapsules coating with appropriate wettability and roughness. Less than 1.5 mg PANI emeraldine was not enough to drive the formation of microcapsules coating while greater than 1.5 mg caused the deposition of melted microcapsules. The similar coating also has promoted greater cells proliferation and attachment compared to other coating variation. Therefore, the utilization of electrodeposition to deposit a drug‐based polymer coating could be implemented to develop DES, in accordance to stent implantation which ultimately aims for enrich endothelialization.

中文翻译:

不同聚苯胺翡翠组合物在电沉积人参皂苷包封的聚(乳酸-共-乙醇酸)微胶囊涂层中的作用:物理化学表征和体外评价。

尽管药物洗脱支架 (DES) 显着减少了再狭窄,但其延迟内皮化的并发症导致了慢性副作用。由于其特定的治疗价值,人参基生物可降解聚合物涂层可以解决这个问题。然而,在金属植入物上沉积这种类型的稳定涂层通常很少见。因此,在本研究中,不同的聚苯胺(PANI)翠绿亚胺组合物采用电沉积包封人参聚(乳酸--乙醇酸)微胶囊包衣。使用衰减全反射傅里叶变换红外光谱、X 射线光电子能谱、扫描电子显微镜、接触角和原子力显微镜仪器分析涂层表面。然后通过评估体外人脐静脉内皮细胞分析(包括细胞毒性和细胞附着评估)来研究一个月的涂层稳定性。1.5 mg PANI 祖母绿有助于形成稳定、均匀和圆形的微胶囊涂层,具有适当的润湿性和粗糙度。小于 1.5 毫克的 PANI 翡翠不足以驱动微胶囊涂层的形成,而大于 1.5 毫克会导致熔化的微胶囊沉积。与其他涂层变化相比,类似的涂层还促进了更大的细胞增殖和附着。因此,根据最终旨在丰富内皮化的支架植入,可以利用电沉积来沉积基于药物的聚合物涂层来开发 DES。
更新日期:2020-02-04
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