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Depressive symptoms in Fabry disease: the importance of coping, subjective health perception and pain.
Orphanet Journal of Rare Diseases ( IF 3.7 ) Pub Date : 2020-01-28 , DOI: 10.1186/s13023-020-1307-y
Simon Körver 1 , Gert J Geurtsen 2 , Carla E M Hollak 1 , Ivo N van Schaik 3 , Maria G F Longo 4 , Marjana R Lima 5 , Leonardo Vedolin 6 , Marcel G W Dijkgraaf 7 , Mirjam Langeveld 1
Affiliation  

BACKGROUND Despite the high prevalence of depressive symptoms in Fabry disease (FD), it is unclear which patient characteristics are important in relation to these symptoms. Additionally, the impact of coping styles in relation to depressive symptoms in FD has been unexplored. Determining the impact of different factors relating to depressive symptoms in FD can guide both prevention and treatment of these symptoms. METHODS Depressive symptoms (Center for Epidemiologic Studies Depression scale (CESD)) and coping styles (Utrecht Coping List) were assessed in a Dutch FD cohort. Other potentially important variables were identified from FD literature and assessed in this cohort. Relations were evaluated using multiple linear models. RESULTS Potentially important variables in FD literature were: pain, unemployment, health perception, being single, comorbidities and stroke. Employed coping styles were "avoidance and brooding", "positivity and problem solving" and "seeking social support". Thirty-one of the 81 FD patients (38%) had depressive symptoms. CESD-scores were lower in patients with better health perception and more "positivity and problem solving" and higher in patients with more pain and "avoidance and brooding". The best model explained 70% (95%CI: 54-76%) of observed variance of the CESD. CONCLUSIONS Depressive symptoms in FD are related to pain, negative health perception and use of specific coping styles. Psychological interventions could be employed to alter coping behavior and alleviate depressive symptoms.

中文翻译:

法布里疾病中的抑郁症状:应对,主观健康感知和疼痛的重要性。

背景技术尽管法布里病(FD)中抑郁症状的患病率很高,但尚不清楚哪些患者特征与这些症状有关是重要的。此外,应对方式与FD抑郁症状相关的影响尚待探索。确定与FD中抑郁症状相关的不同因素的影响,可以指导这些症状的预防和治疗。方法在荷兰FD队列中评估了抑郁症状(流行病学研究中心抑郁量表(CESD))和应对方式(乌特勒支应对清单)。从FD文献中确定了其他可能重要的变量,并在此队列中进行了评估。使用多个线性模型评估关系。结果FD文献中潜在的重要变量是:疼痛,失业,健康感知,单身,合并症和中风。使用的应对方式是“回避和沉思”,“积极和解决问题”以及“寻求社会支持”。81名FD患者中有31名(38%)有抑郁症状。在具有更好的健康感知和更多的“积极性和解决问题”的患者中,CESD得分较低,而在具有更多痛苦和“回避和沉思”的患者中,CESD得分较高。最佳模型解释了观察到的CESD方差的70%(95%CI:54-76%)。结论FD的抑郁症状与疼痛,对健康的负面看法以及特定应对方式的使用有关。可以采用心理干预来改变应对行为并缓解抑郁症状。
更新日期:2020-01-30
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