BACKGROUND Trans-oral endoscopic thyroidectomy allows obviating scar of the neck that expects to gain quality of life (QOL). However, the benefit of the QOL from this technique has not been adequately investigated, therefore, this study compared the QOL outcomes, including cosmetic outcomes, between thyroidectomy by trans-oral endoscopy and conventional open surgery. METHODS A study was conducted from January 30, 2017 to November 10, 2018. Thirty-two and 38 patients underwent trans-oral endoscopic thyroid surgery and conventional open surgery, respectively. Their quality of life was evaluated at 2, 6, and 12 weeks postoperatively using a thyroid surgery-specific questionnaire and a 36-item short-form questionnaire. RESULTS Trans-oral endoscopic group, patients were younger and presented with smaller thyroid nodules (p < 0.05). Regarding surgical outcomes, there were no statistically significant differences between the two groups. Mean operative time was significantly longer in the trans-oral endoscopic group (p < 0.05). The quality of life parameters in the trans-oral endoscopic group was significantly better than in the conventional surgery group (p < 0.05). These parameters included reduction of physical activity, psychosocial impairment, the role of physic, and emotion at 2 weeks after surgery; swallowing impairment, psychosocial impairment, the role of physic, social function and mental health 6 weeks after surgery; tingling and feeling of vitality at 12 weeks after surgery. Cosmetic outcomes and overall satisfaction were significantly better in the trans-oral endoscopic group than in the conventional surgery group at all of our follow up times (p < 0.05). CONCLUSIONS The trans-oral endoscopic approach allows real scarless on the skin with better cosmetic and QOL outcomes. TRIAL REGISTRATION This trial was retrospectively registered at the ClinicalTrial.gov (NCT03048539), registered on 4 March 2017.

中文翻译：

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比较经口内镜甲状腺手术和常规开放式手术患者的生活质量。

背景技术经口内窥镜甲状腺切除术可以消除期望获得生活质量（QOL）的颈部疤痕。然而，该技术对QOL的益处尚未得到充分研究，因此，本研究比较了经口内镜甲状腺切除术与常规开放手术之间的QOL结局，包括美容结局。方法自2017年1月30日至2018年11月10日进行研究。分别对32例和38例患者进行经口内镜甲状腺手术和常规开放手术。在术后第2、6和12周使用甲状腺手术专用问卷和36项简短问卷对他们的生活质量进行了评估。结果经口内窥镜检查组年龄较小，甲状腺结节较小（p <0.05）。关于手术结果，两组之间在统计学上没有显着差异。经口内镜组的平均手术时间明显更长（p <0.05）。经口内窥镜检查组的生活质量参数明显优于常规手术组（p <0.05）。这些参数包括术后2周运动量减少，社会心理障碍，身体作用和情绪下降；术后6周吞咽障碍，社会心理障碍，身体，社会功能和心理健康的作用；术后12周有刺痛感和活力感。在我们所有的随访时间中，经口内镜组的美容结局和总体满意度均明显优于传统手术组（p <0.05）。结论经口腔内窥镜检查方法可以使皮肤真正无疤，并具有更好的美容和QOL效果。试验注册该试验在2017年3月4日注册的ClinicalTrial.gov（NCT03048539）上进行了回顾性注册。