BACKGROUND We investigated the association between a combination of two markers, peripheral (PEC) and bronchoalveolar lavage (BAL) eosinophil percentage (BEP), and oxygen requirements in patients with acute eosinophilic pneumonia (AEP). METHODS We retrospectively reviewed the medical records of patients with AEP treated at the Armed Forces Capital Hospital between May 2012 and May 2017. We used correlation analyses to assess the association between PEC/BEP and clinical outcomes in AEP patients. Receiver operating characteristic (ROC) curve analyses were used to calculate the cut-off value for BEP that categorised patients requiring a significant oxygen supply. The BAL/blood eosinophil (BBE) score was introduced to stratify patients with peripheral eosinophilia and elevated BEP. Clinical characteristics and outcomes were compared between the different groups. Multiple logistic regression was performed for significant oxygen requirements using two different models using age, C-reactive protein (CRP), smoking duration, and BBE score (model 1) and age, CRP, BEP, and PEC (model 2). RESULTS Among the 338 patients, 99.7% were male, and their mean age was 20.4 ± 1.4 years. Only 0.6% of patients were never smokers and the mean number of smoking days was 26.2 ± 25.4. Correlation analyses revealed that both the PaO2/FiO2 ratio and duration of oxygen supply were associated with BEP. ROC curve analyses indicated a cut-off level of 41.5%. Patients with a high BBE score had favourable outcomes in terms of hypoxemia, hospital days, intensive care unit admission, oxygen supply days, and steroid treatment days. Multiple logistic regression revealed that BEP and BBE score tended to be associated with significant oxygen requirements. CONCLUSIONS In this study, we revealed that both peripheral and BAL eosinophilia is associated with favourable outcomes in AEP patients.

中文翻译：

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急性嗜酸性粒细胞性肺炎患者外周血/支气管肺泡灌洗液嗜酸粒细胞增多与大量需氧量之间的关联。

背景我们研究了急性外周嗜酸性粒细胞性肺炎（AEP）患者外周血（PEC）和支气管肺泡灌洗（BAL）嗜酸性粒细胞百分比（BEP）两种标记物与需氧量之间的关联。方法我们回顾性研究了2012年5月至2017年5月在武装部队首都医院接受治疗的AEP患者的病历。我们使用相关分析评估了PEC / BEP与AEP患者临床结局之间的关联。接收者操作特征（ROC）曲线分析用于计算BEP的临界值，该临界值将需要大量氧气供应的患者分类。引入BAL /血液嗜酸性粒细胞（BBE）评分以对外周嗜酸性粒细胞增多和BEP升高的患者进行分层。比较不同组之间的临床特征和结果。使用年龄，C反应蛋白（CRP），吸烟时间和BBE评分（模型1）以及年龄，CRP，BEP和PEC（模型2）这两个不同的模型，对明显的需氧量进行了多元逻辑回归。结果在338例患者中，男性占99.7％，平均年龄为20.4±1.4岁。只有0.6％的患者从不吸烟，平均吸烟天数为26.2±25.4。相关分析表明，PaO2 / FiO2比和供氧时间均与BEP有关。ROC曲线分析表明临界水平为41.5％。BBE评分高的患者在低氧血症，住院天数，重症监护病房入院，氧气供应天数和类固醇治疗天数方面均具有良好的预后。多元logistic回归显示，BEP和BBE得分往往与明显的需氧量相关。结论在这项研究中，我们发现AEP患者外周血和BAL嗜酸性粒细胞增多均与良好的预后相关。