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Patient-adapted organ absorbed dose and effective dose estimates in pediatric 18F-FDG positron emission tomography/computed tomography studies.
BMC Medical Imaging ( IF 2.7 ) Pub Date : 2020-01-29 , DOI: 10.1186/s12880-020-0415-4
Brian M Quinn 1 , Yiming Gao 1 , Usman Mahmood 1 , Neeta Pandit-Taskar 2 , Gerald Behr 2 , Pat Zanzonico 1, 2 , Lawrence T Dauer 1, 2
Affiliation  

BACKGROUND Organ absorbed doses and effective doses can be used to compare radiation exposure among medical imaging procedures, compare alternative imaging options, and guide dose optimization efforts. Individual dose estimates are important for relatively radiosensitive patient populations such as children and for radiosensitive organs such as the eye lens. Software-based dose calculation methods conveniently calculate organ dose using patient-adjusted and examination-specific inputs. METHODS Organ absorbed doses and effective doses were calculated for 429 pediatric 18F-FDG PET-CT patients. Patient-adjusted and scan-specific information was extracted from the electronic medical record and scanner dose-monitoring software. The VirtualDose and OLINDA/EXM (version 2.0) programs, respectively, were used to calculate the CT and the radiopharmaceutical organ absorbed doses and effective doses. Patients were grouped according to age at the time of the scan as follows: less than 1 year old, 1 to 5 years old, 6 to 10 years old, 11 to 15 years old, and 16 to 17 years old. RESULTS The mean (+/- standard deviation, range) total PET plus CT effective dose was 14.5 (1.9, 11.2-22.3) mSv. The mean (+/- standard deviation, range) PET effective dose was 8.1 (1.2, 5.7-16.5) mSv. The mean (+/- standard deviation, range) CT effective dose was 6.4 (1.8, 2.9-14.7) mSv. The five organs with highest PET dose were: Urinary bladder, heart, liver, lungs, and brain. The five organs with highest CT dose were: Thymus, thyroid, kidneys, eye lens, and gonads. CONCLUSIONS Organ and effective dose for both the CT and PET components can be estimated with actual patient and scan data using commercial software. Doses calculated using software generally agree with those calculated using dose conversion factors, although some organ doses were found to be appreciably different. Software-based dose calculation methods allow patient-adjusted dose factors. The effort to gather the needed patient data is justified by the resulting value of the characterization of patient-adjusted dosimetry.

中文翻译:

在儿科18F-FDG正电子发射断层扫描/计算机断层扫描研究中,患者适应的器官吸收剂量和有效剂量估计值。

背景技术器官吸收的剂量和有效剂量可用于比较医学成像程序之间的放射线照射,比较替代成像选项以及指导剂量优化工作。个体剂量估计对于对辐射敏感的患者群体(例如儿童)和对辐射敏感的器官(例如眼镜)非常重要。基于软件的剂量计算方法可方便地使用患者调整和特定于检查的输入来计算器官剂量。方法计算429例儿科18F-FDG PET-CT患者的器官吸收剂量和有效剂量。从电子病历和扫描仪剂量监控软件中提取了患者调整的和特定于扫描的信息。分别使用VirtualDose和OLINDA / EXM(2.0版)程序,用于计算CT和放射性药物器官的吸收剂量和有效剂量。根据扫描时的年龄将患者分组如下:小于1岁,1至5岁,6至10岁,11至15岁和16至17岁。结果平均总PET加上CT有效剂量(+/-标准偏差,范围)为14.5(1.9,11.2-22.3)mSv。PET有效剂量的平均值(+/-标准偏差,范围)为8.1(1.2,5.7-16.5)mSv。CT有效剂量的平均值(+/-标准偏差,范围)为6.4(1.8,2.9-14.7)mSv。最高PET剂量的五个器官是:膀胱,心脏,肝脏,肺和大脑。CT剂量最高的五个器官是:胸腺,甲状腺,肾脏,晶状体和性腺。结论CT和PET组件的器官和有效剂量可以使用实际的患者和扫描数据通过商业软件进行估算。尽管发现某些器官剂量明显不同,但使用软件计算的剂量通常与使用剂量转换因子计算的剂量一致。基于软件的剂量计算方法允许患者调整剂量系数。收集所需的患者数据的努力通过调整后的患者剂量学表征的结果值来证明。
更新日期:2020-04-22
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