Twenty-one β-dihydroagarofuran-type sesquiterpenes compounds were isolated from the dry roots of Tripterygium wilfordii, including eight new β-dihydroagarofuran-type sesquiterpenes nature products (2, 6, 8-13) and thirteen known compounds, the structure of these compounds were elucidated by extensive NMR spectroscopic and mass spectrometric analysis. Among all isolated compound 10 exhibited cytotoxicity toward five carcinoma cells, including A549, HOS, MCF-7, MDA-MB-231 and MCF7/TAMR cells, with half-maximal inhibition of cell proliferation values ranging from 13.77 to 25.19 μM.

中文翻译：

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雷公藤根中的二氢-β -agarofuran型倍半萜及其细胞毒活性

二十一β- dihydroagarofuran型倍半萜化合物从干根中分离雷公藤，包括八个新β- dihydroagarofuran型倍半萜类天然产物（2，6,8 - 13）和13种已知的化合物，这些化合物的结构通过广泛的NMR光谱和质谱分析来阐明。在所有分离的化合物10中，对五种癌细胞（包括A549，HOS，MCF-7，MDA-MB-231和MCF7 / TAMR细胞）表现出细胞毒性，对细胞增殖值的半数最大抑制范围为13.77至25.19μM。