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Effectiveness of herbal medicines for weight loss: A systematic review and meta-analysis of randomized controlled trials.
Diabetes, Obesity and Metabolism ( IF 5.8 ) Pub Date : 2020-02-15 , DOI: 10.1111/dom.13973
Alison Maunder 1 , Erica Bessell 1 , Romy Lauche 2, 3 , Jon Adams 2 , Amanda Sainsbury 1 , Nicholas R Fuller 1
Affiliation  

AIM To update the available evidence on the efficacy and safety of complementary medicines to assist in weight loss by conducting a systematic review and meta-analysis of herbal medicines for weight loss. METHODS Four electronic databases (Medline, Embase, CINAHL and Web of Science) were searched from inception until August 2018. A total of 54 randomized placebo-controlled trials of healthy overweight or obese adults were identified. Meta-analyses were conducted for herbal medicines with ≥4 studies available. Weight differences of ≥2.5 kg were considered clinically significant. RESULTS As a single agent, only Phaseolus vulgaris resulted in a statistically significant weight loss compared to placebo, although this was not considered clinically significant. No effect was seen for Camellia sinensis or Garcinia cambogia. Statistically, but not clinically, significant differences were observed for combination preparations containing C. sinensis, P. vulgaris or Ephedra sinica. Of the herbal medicines trialled in ≤3 randomized controlled trials, statistically and clinically significant weight loss compared to placebo was reported for Irvingia gabonensis, Cissus quadrangularis, and Sphaeranthus indicus combined with Garcinia mangostana, among others, but these findings should be interpreted cautiously because of the small number of studies, generally poor methodological quality, and poor reporting of the herbal medicine interventions. Most herbal medicines appeared safe for consumption over the short duration of the studies (commonly ≤12 weeks). Some warrant further investigation to determine effect size, dosage and long-term safety. CONCLUSION There is currently insufficient evidence to recommend any of the herbal medicines for weight loss included in the present review.

中文翻译:

草药减肥的有效性:随机对照试验的系统评价和荟萃分析。

目的通过对草药减肥的系统评价和荟萃分析,更新有关辅助药物的功效和安全性以帮助减肥的现有证据。方法从开始到2018年8月,共检索了四个电子数据库(Medline,Embase,CINAHL和Web of Science)。共鉴定了54项健康超重或肥胖成年人的随机安慰剂对照试验。对草药进行了荟萃分析,有≥4项研究可用。体重差异≥2.5kg被认为具有临床意义。结果与安慰剂相比,仅菜豆作为单药可导致统计学上显着的体重减轻,尽管这在临床上不被认为是有意义的。没有观察到山茶或藤黄果的作用。从统计上讲 但是在临床上没有发现,对于含有中华隐孢子虫,寻常体育或麻黄的组合制剂,观察到了显着差异。在≤3个随机对照试验中试验过的草药中,据报道Irvingia gabonensis,Cussus quadrangularis和Sphaeranthus indicus结合藤黄与安慰剂相比,体重与安慰剂相比有统计学和临床​​意义的减轻,但由于以下原因,应谨慎解释这些发现:研究数量少,方法学质量普遍较差,草药干预措施的报告也较差。在研究的短时间内(通常≤12周),大多数草药似乎可以安全食用。有些需要进一步研究以确定效果的大小,剂量和长期安全性。
更新日期:2020-02-15
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