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Unusual Two-Step Assembly of a Minimalistic Dipeptide-Based Functional Hypergelator.
Advanced Materials ( IF 29.4 ) Pub Date : 2020-01-27 , DOI: 10.1002/adma.201906043
Priyadarshi Chakraborty 1 , Yiming Tang 2 , Tomoya Yamamoto 3 , Yifei Yao 2 , Tom Guterman 1 , Shai Zilberzwige-Tal 1 , Nofar Adadi 4 , Wei Ji 1 , Tal Dvir 1, 4 , Ayyalusamy Ramamoorthy 3 , Guanghong Wei 2 , Ehud Gazit 1, 4
Affiliation  

Self-assembled peptide hydrogels represent the realization of peptide nanotechnology into biomedical products. There is a continuous quest to identify the simplest building blocks and optimize their critical gelation concentration (CGC). Herein, a minimalistic, de novo dipeptide, Fmoc-Lys(Fmoc)-Asp, as an hydrogelator with the lowest CGC ever reported, almost fourfold lower as compared to that of a large hexadecapeptide previously described, is reported. The dipeptide self-assembles through an unusual and unprecedented two-step process as elucidated by solid-state NMR and molecular dynamics simulation. The hydrogel is cytocompatible and supports 2D/3D cell growth. Conductive composite gels composed of Fmoc-Lys(Fmoc)-Asp and a conductive polymer exhibit excellent DNA binding. Fmoc-Lys(Fmoc)-Asp exhibits the lowest CGC and highest mechanical properties when compared to a library of dipeptide analogues, thus validating the uniqueness of the molecular design which confers useful properties for various potential applications.

中文翻译:

简约的基于二肽的功能性超凝胶剂的不寻常的两步组装。

自组装的肽水凝胶代表了肽纳米技术在生物医学产品中的实现。人们一直在寻找最简单的结构单元并优化其临界胶凝浓度(CGC)。在本文中,报道了一种极简的从头二肽Fmoc-Lys(Fmoc)-Asp,它是迄今为止报道的CGC最低的水凝胶剂,与以前所述的大六肽相比,几乎降低了四倍。固态NMR和分子动力学模拟表明,二肽通过不寻常且前所未有的两步过程自组装。水凝胶具有细胞相容性,并支持2D / 3D细胞生长。由Fmoc-Lys(Fmoc)-Asp和导电聚合物组成的导电复合凝胶具有出色的DNA结合力。
更新日期:2020-03-03
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