The members of the BCL-2 associated athanogene (BAG) family participate in the regulation of a variety of interrelated physiological processes, such as autophagy, apoptosis, and protein homeostasis. Under normal circumstances, the six BAG members described in mammals (BAG1-6) principally assist the 70 kDa heat-shock protein (HSP70) in protein folding; however, their role as oncogenes is becoming increasingly evident. Deregulation of the BAG multigene family has been associated with cell transformation, tumor recurrence, and drug resistance. In addition to BAG overexpression, BAG members are also involved in many oncogenic protein-protein interactions (PPIs). As such, either the inhibition of overloading BAGs or of specific BAG-client protein interactions could have paramount therapeutic value. In this review, we will examine the role of each BAG family member in different malignancies, focusing on their modular structure, which enables interaction with a variety of proteins to exert their pro-tumorigenic role. Lastly, critical remarks on the unmet needs for proposing effective BAG inhibitors will be pointed out.

中文翻译：

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BAG的生活：每个联系都与癌症息息相关。

BCL-2相关的致癌基因（BAG）家族的成员参与各种相互关联的生理过程的调控，例如自噬，细胞凋亡和蛋白质稳态。在正常情况下，哺乳动物（BAG1-6）中描述的六个BAG成员主要协助70 kDa热休克蛋白（HSP70）进行蛋白折叠。然而，它们作为癌基因的作用越来越明显。BAG多基因家族的失调与细胞转化，肿瘤复发和耐药性有关。除了BAG过表达，BAG成员还参与许多致癌蛋白-蛋白相互作用（PPI）。因此，抑制超载BAG或特定BAG-客户蛋白质相互作用可能具有最重要的治疗价值。在这篇评论中 我们将研究每个BAG家族成员在不同恶性肿瘤中的作用，重点是它们的模块结构，该模块结构可与多种蛋白质相互作用以发挥其促肿瘤作用。最后，将指出对提出有效BAG抑制剂未满足需求的批评。