Precise and efficient use of genome editing tools are hampered by the introduction of DNA double-strand breaks, donor DNA templates, or homology-directed repair. A recent study expands the genome editing toolbox with the introduction of prime editing, which overcomes previous challenges and introduces insertions, deletions, and all putative 12 types of base-to-base conversions in human cells.

中文翻译：

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Prime编辑：基因组编辑的新方法。

DNA双链断裂，供体DNA模板或同源性指导的修复方法妨碍了基因组编辑工具的精确和有效使用。一项最新研究通过引入主要编辑功能扩展了基因组编辑工具箱，从而克服了先前的挑战，并引入了人类细胞中的插入，缺失和所有假定的12种类型的碱基间转换。