The abuse of antibiotics has led to the enhancement of bacterial drug resistance, which has aroused widespread concern. In our study, an unusual polymer (PADAAC) with aldehyde, vinyl and azo groups was obtained by copolymerization of allyl diazoacetate (ADA) and acrolein (AC). We fabricated a series of hydrogels (PA0AM, PA5AM, PA10AM and PA20AM) by incorporation PADAAC into the acrylamide and N, N’-methylene bis(acrylamide) networks, which can suppress bacterial growth and kill the bacteria with > 95%. All the hydrogels possessed low cytotoxicity. More remarkably, the aldehyde groups were protected amino groups via a simple imine reaction. Protected PA20AM had no effect on the bacteria, while deprotected PA20AM recovered its antimicrobial property against Staphylococcus aureus (killing efficiency: 96.1%), Escherichia coli (killing efficiency: 98.3%) and methicillin-resistant Staphylococcus aureus (MRSA) (killing efficiency: 95.0%) after removing the amino groups. PA20AM and deprotected PA20AM also exhibited good antimicrobial property in vivo.

抗生素的滥用导致细菌耐药性的增强，引起了广泛的关注。在我们的研究中，通过重氮乙酸烯丙酯（ADA）和丙烯醛（AC）的共聚反应获得了具有醛，乙烯基和偶氮基团的不寻常聚合物（PADAAC）。通过将PADAAC掺入丙烯酰胺和N，N'-亚甲基双（丙烯酰胺）网络中，我们制备了一系列水凝胶（PA0AM，PA5AM，PA10AM和PA20AM），可以抑制细菌生长并杀死细菌，其杀灭率大于95％。所有的水凝胶都具有低细胞毒性。更明显地，醛基通过简单的亚胺反应被保护为氨基。受保护的PA20AM对细菌没有影响，而去保护的PA20AM恢复了对金黄色葡萄球菌的抗菌性能（杀死效率为96.1％），除去氨基后，大肠杆菌（杀灭效率：98.3％）和耐甲氧西林的金黄色葡萄球菌（杀伤效率：95.0％）。PA20AM和去保护的PA20AM在体内也表现出良好的抗菌性能。