The present study was conducted to investigate the effects of CoQ10 dietary supplementation on growth performance, feed utilization, blood profile, immune response, and oxidative status of Nile tilapia (12.4 ± 0.11 g, initial body weight). Five experimental diets were formulated containing CoQ10 at levels of 0, 10, 20, 30, 40 mg kg-1 diet (D1, D2, D3, D4, and D5, respectively). The results of a 56-days feeding trial showed that, significantly higher weight gain % (WG %), specific growth rate (SGR), feed intake (FI), and feed efficiency ratio (FER) were recorded in fish groups fed diets supplemented with different levels of CoQ10 than fish fed the control diet, while survival rate (SR%), condition factor (CF), hepatosomatic index (HSI) and viscerasomatic index (VSI) showed no obvious differences (P > 0.05) among all experimental groups. The highest activities of digestive enzymes (protease, amylase, and lipase) were recorded in D3, D4, and D5 groups. Moreover, blood status of all experimental fish was within normal rates and significant alterations were only in the case of glucose, cortisol, total cholesterol (T-Chol), triglycerides, and total protein (TP), where fish fed on D3, D4 and D5 diets exhibited lower values of glucose, cortisol, T-Chol, and triglycerides and higher values of TP. Furthermore, the lowest values of immune response [lysozyme, bactericidal, respiratory burst (NBT), and alternative complement pathway activities (ACP)], antioxidant capacity and oxidative related genes expressions [superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX)] resulted from feeding on the basal diet (D1) compared to CoQ10 diets, especially with its high levels {≥20 mg kg-1 diet (D3, D4, and D5)} in most cases. In conclusion, our results suggest that the use of ≥20 mg CoQ10 kg-1 diet improves the growth and health being of Nile tilapia.

中文翻译：

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评估辅酶Q10饮食对尼罗罗非鱼（Oreochromis niloticus）的生长性能，消化酶，血液健康，免疫应答和氧化相关基因表达的有效性。

本研究旨在研究辅酶Q10饮食对尼罗罗非鱼（12.4±0.11 g，初始体重）的生长性能，饲料利用率，血液状况，免疫反应和氧化状态的影响。配制了五种含CoQ10含量为0、10、20、30、40 mg kg-1饮食的实验饮食（分别为D1，D2，D3，D4和D5）。一项为期56天的饲喂试验的结果表明，在补充饮食的鱼群中，记录到的体重增加％（WG％），比生长速率（SGR），饲料摄入量（FI）和饲料效率比（FER）明显更高。 CoQ10水平与鱼类相比，对照组的存活率（SR％），条件因子（CF），肝体指数（HSI）和内脏躯体指数（VSI）在所有实验组之间均无明显差异（P> 0.05） 。D3，D4和D5组的消化酶（蛋白酶，淀粉酶和脂肪酶）的活性最高。此外，所有实验鱼的血液状况均在正常水平之内，并且只有在葡萄糖，皮质醇，总胆固醇（T-Chol），甘油三酸酯和总蛋白（TP）的情况下才发生显着变化，其中以D3，D4和D5日粮的葡萄糖，皮质醇，T-Chol和甘油三酸酯的值较低，而TP的值较高。此外，免疫应答的最低值[溶菌酶，杀菌，呼吸爆发（NBT）和替代补体途径活性（ACP）]，抗氧化能力和氧化相关基因的表达[超氧化物歧化酶（SOD），过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GPX）]是由于与CoQ10日粮相比，以基础日粮（D1）为食，尤其是在大多数情况下，其{{20 mg kg-1饮食（D3，D4和D5）高水平）}。总之，我们的结果表明，使用≥20 mg CoQ10 kg-1的饮食可改善尼罗罗非鱼的生长和健康状况。