CSDE1 (cold shock domain containing E1) plays a key role in translational reprogramming, which determines the fate of a number of RNAs during biological processes. Interestingly, the role of CSDE1 is bidirectional. It not only promotes and represses the translation of RNAs but also increases and decreases the abundance of RNAs. However, the mechanisms underlying this phenomenon are still unknown. In this review, we propose a "protein-RNA connector" model to explain this bidirectional role and depict its three versions: sequential connection, mutual connection and facilitating connection. As described in this molecular model, CSDE1 binds to RNAs and cooperates with other protein regulators. CSDE1 connects with different RNAs and their regulators for different purposes. The triple complex of CSDE1, a regulator and an RNA reprograms translation in different directions for each transcript. Meanwhile, a number of recent studies have found important roles for CSDE1 in human diseases. This model will help us to understand the role of CSDE1 in translational reprogramming and human diseases. Video Abstract.

中文翻译：

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CSDE1在翻译重编程和人类疾病中的作用。

CSDE1（含有E1的冷休克结构域）在翻译重编程中起关键作用，后者决定了生物过程中许多RNA的命运。有趣的是，CSDE1的作用是双向的。它不仅促进和抑制RNA的翻译，而且增加和减少RNA的丰度。但是，这种现象的潜在机制仍然未知。在这篇综述中，我们提出了一个“蛋白质-RNA连接器”模型来解释这种双向作用，并描述了它的三个版本：顺序连接，相互连接和促进连接。如该分子模型中所述，CSDE1与RNA结合并与其他蛋白质调节剂协同作用。CSDE1连接不同的RNA及其调节剂以达到不同的目的。CSDE1的三元复合体，调节子和RNA重新编程每个转录本的方向不同。同时，最近的许多研究发现CSDE1在人类疾病中的重要作用。该模型将帮助我们了解CSDE1在翻译重编程和人类疾病中的作用。录像摘要。