Ionic signalling is the most ancient form of regulation of cellular functions in response to environmental challenges. Signals, mediated by Na+ fluxes and spatio-temporal fluctuations of Na+ concentration in cellular organelles and cellular compartments contribute to the most fundamental cellular processes such as membrane excitability and energy production. At the very core of ionic signalling lies the Na+-K+ ATP-driven pump (or NKA) which creates trans-plasmalemmal ion gradients that sustain ionic fluxes through ion channels and numerous Na+-dependent transporters that maintain cellular and tissue homeostasis. Here we present a brief account of the history of research into NKA, Na+ -dependent transporters and Na+ signalling.

中文翻译：

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多功能Na +离子介导激发和细胞稳态：Na +泵和Na + / Ca2 +交换剂概念的发展。

离子信号是响应环境挑战而调节细胞功能的最古老形式。Na +通量和细胞器和细胞区室中Na +浓度的时空波动介导的信号促成最基本的细胞过程，例如膜兴奋性和能量产生。离子信号传导的核心是Na + -K + ATP驱动的泵（或NKA），该泵产生跨血浆离子梯度，该梯度可维持通过离子通道的离子通量，并维持细胞和组织体内平衡的许多Na +依赖性转运蛋白。在这里，我们简要介绍了NKA，依赖Na +的转运蛋白和Na +信号传导的研究历史。