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Characteristics of youth at high risk for bipolar disorder compared to youth with bipolar I or II disorder.
Journal of Psychiatric Research ( IF 4.8 ) Pub Date : 2020-01-25 , DOI: 10.1016/j.jpsychires.2020.01.010
Marc J Weintraub 1 , Christopher D Schneck 2 , Patricia D Walshaw 1 , Kiki D Chang 3 , Manpreet K Singh 4 , David A Axelson 5 , Boris Birmaher 6 , David J Miklowitz 1
Affiliation  

Significant efforts have been undertaken to characterize the phenomenology of the high-risk period for bipolar disorder (BD) through the examination of youth at familial risk (i.e., having a first- or second-degree relative with BD) or clinical high risk for the disorder (i.e., youth with BD Not Otherwise Specified [NOS] or major depressive disorder [MDD]). However, little is known about the phenomenology of youth at both familial and clinical high risk for BD. In this study, we examined the clinical and psychosocial characteristics of youth at familial and clinical high risk (HR) for BD, and compared these characteristics to those of youth with BD I and II. Both groups were recruited based on current, active mood symptoms from separate randomized trials of family therapy. A total of 127 HR youth were evaluated: 52 (40.9%) were diagnosed with BD-NOS and 75 (59.1%) were diagnosed with MDD. Compared to adolescents with BD I and II (n = 145), HR youth had higher rates of anxiety disorders, and comparable rates of attention-deficit/hyperactivity disorder and oppositional defiant disorder/conduct disorder. Manic symptom severity and psychosocial functioning were progressively more impaired consistent with diagnostic severity: BD I > BD II > BD-NOS > MDD. Nonetheless, HR youth exhibited depressive symptom severity that was comparable to adolescents with BD I. These results provide further support for the high rates of anxiety disorders and premorbid dysfunction in addition to active mood symptoms for youth at risk for BD, and suggest anxiety is an important phenomenological characteristic and treatment target in the high-risk period.

中文翻译:

与患有I型或II型双相情感障碍的年轻人相比,处于双相情感障碍的高风险年轻人的特征。

通过检查有家族风险的年轻人(即与BD有一级或二级亲戚)或患有这种疾病的临床高风险人群,已经做出了巨大的努力来表征双相情感障碍(BD)高危期的现象学。疾病(即未另外指定BD的年轻人[NOS]或重度抑郁症[MDD])。然而,关于家族性和临床BD高危青年的现象学知之甚少。在这项研究中,我们检查了患有BD家族和临床高风险(HR)的青年的临床和社会心理特征,并将这些特征与BD I和BD的青年进行了比较。两组都是根据来自单独的家庭治疗随机试验的当前活跃情绪症状招募的。总共对127名HR青年进行了评估:52(40。9%的患者被诊断出BD-NOS,而75例(59.1%)被诊断出患有MDD。与BD I和BD II青少年(n = 145)相比,HR青年的焦虑症发生率更高,注意力缺陷/多动障碍和对立违抗性障碍/品行障碍的发生率相当。躁狂症状严重程度和社会心理功能逐渐受损,与诊断严重程度相符:BD I> BD II> BD-NOS> MDD。尽管如此,HR青年表现出的抑郁症状严重程度可与BD I青少年相媲美。这些结果为高危焦虑症和病前功能障碍提供了进一步的支持,此外还有处于BD风险中的青年的活跃情绪症状,这表明焦虑是一种高危期的重要现象学特征和治疗目标。1%)被诊断患有MDD。与BD I和BD II青少年(n = 145)相比,HR青年的焦虑症发生率更高,注意力缺陷/多动障碍和对立违抗性障碍/品行障碍的发生率相当。躁狂症状严重程度和社会心理功能逐渐受损,与诊断严重程度相符:BD I> BD II> BD-NOS> MDD。尽管如此,HR青年表现出的抑郁症状严重程度可与BD I青少年相媲美。这些结果为高危焦虑症和病前功能障碍提供了进一步的支持,此外还有处于BD风险中的青年的活跃情绪症状,这表明焦虑是一种高危期的重要现象学特征和治疗目标。1%)被诊断患有MDD。与BD I和BD II青少年(n = 145)相比,HR青年的焦虑症发生率更高,注意力缺陷/多动障碍和对立违抗性障碍/品行障碍的发生率相当。躁狂症状严重程度和社会心理功能逐渐受损,与诊断严重程度相符:BD I> BD II> BD-NOS> MDD。尽管如此,HR青年表现出的抑郁症状严重程度可与BD I青少年相媲美。这些结果为高危焦虑症和病前功能障碍提供了进一步的支持,此外还有处于BD风险中的青年的活跃情绪症状,这表明焦虑是一种高危期的重要现象学特征和治疗目标。HR青年的焦虑症发生率更高,注意缺陷/多动障碍和对立违抗性障碍/品行障碍的发生率相当。躁狂症状严重程度和社会心理功能逐渐受损,与诊断严重程度相符:BD I> BD II> BD-NOS> MDD。尽管如此,HR青年表现出的抑郁症状严重程度可与BD I青少年相提并论。这些结果为高危焦虑症和病前功能障碍提供了进一步的支持,此外还有处于BD风险中的青年的活跃情绪症状,这表明焦虑是一种高危期的重要现象学特征和治疗目标。HR青年的焦虑症发生率更高,注意缺陷/多动障碍和对立违抗性障碍/品行障碍的发生率相当。躁狂症状严重程度和社会心理功能逐渐受损,与诊断严重程度相符:BD I> BD II> BD-NOS> MDD。尽管如此,HR青年表现出的抑郁症状严重程度可与BD I青少年相媲美。这些结果为高危焦虑症和病前功能障碍提供了进一步的支持,此外还有处于BD风险中的青年的活跃情绪症状,这表明焦虑是一种高危期的重要现象学特征和治疗目标。和注意缺陷/多动障碍和对立违抗性障碍/品行障碍的比率相当。躁狂症状严重程度和社会心理功能逐渐受损,与诊断严重程度相符:BD I> BD II> BD-NOS> MDD。尽管如此,HR青年表现出的抑郁症状严重程度可与BD I青少年相媲美。这些结果为高危焦虑症和病前功能障碍提供了进一步的支持,此外还有处于BD风险中的青年的活跃情绪症状,这表明焦虑是一种高危期的重要现象学特征和治疗目标。和注意缺陷/多动障碍和对立违抗性障碍/品行障碍的比率相当。躁狂症状严重程度和社会心理功能逐渐受损,与诊断严重程度相符:BD I> BD II> BD-NOS> MDD。尽管如此,HR青年表现出的抑郁症状严重程度可与BD I青少年相媲美。这些结果为高危焦虑症和病前功能障碍提供了进一步的支持,此外还有处于BD风险中的青年的活跃情绪症状,这表明焦虑是高危期的重要现象学特征和治疗目标。
更新日期:2020-01-26
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