当前位置: X-MOL 学术PLOS ONE › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Impact of lower limb osteoarthritis on health-related quality of life: A cross-sectional study to estimate the expressed loss of utility in the Spanish population.
PLOS ONE ( IF 3.7 ) Pub Date : 2020-01-24 , DOI: 10.1371/journal.pone.0228398
Jesús Martín-Fernández 1, 2, 3 , Roberto García-Maroto 4, 5 , Amaia Bilbao 3, 6, 7 , Lidia García-Pérez 3, 8 , Blanca Gutiérrez-Teira 9 , Antonio Molina-Siguero 10 , Juan Carlos Arenaza 3, 11 , Vanesa Ramos-García 8 , Gemma Rodríguez-Martínez 12 , Fco Javier Sánchez-Jiménez 13 , Gloria Ariza-Cardiel 1, 3
Affiliation  

OBJECTIVE Osteoarthritis of the lower limb (OALL) worsens health-related quality of life (HRQL), but this impact has not been quantified with standardized measures. We intend to evaluate the impact of OALL on HRQL through measures based on individual preferences in comparison to the general population. METHODS A cross-sectional study was designed. A total of 6234 subjects aged 50 years or older without OALL were selected from the Spanish general population (National Health Survey 2011-12). An opportunistic sample of patients aged 50 years or older diagnosed with hip (n = 331) or knee osteoarthritis (n = 393), using the American Rheumatism Association criteria, was recruited from six hospitals and 21 primary care centers in Vizcaya, Madrid and Tenerife between January and December 2015. HRQL was measured with the EQ-5D-5L, and the results were transformed into utility scores. Sociodemographic variables (age, sex, social group, cohabitation), number of chronic diseases, and body mass index were considered. The clinical stage of OALL was collected using the Western Ontario and McMaster Universities Osteoarthritis Index and the Oxford hip score and Oxford knee score. Generalized linear models were constructed using the utility index as the dependent variable. RESULTS HRQL expressed by OALL patients was significantly worse than this of the general population. After adjustment for sociodemographic and clinical characteristics, the mean utility loss was -0.347 (95% CI: -0.390, -0.303) for osteoarthritis of the hip and -0.295 (95% CI: -0.336, -0.255) for osteoarthritis of the knee. OALL patients who were treated at a hospital had an additional utility loss of -0.112 (95% CI: -0.158, -0.065). CONCLUSION OALL has a great impact on HRQL. People with OALL perceive a utility loss of approximately 0.3 points compared to the general population without osteoarthritis, which is very high in relation to the utility loss reported for other chronic diseases and for arthritis in general.

中文翻译:

下肢骨关节炎对与健康相关的生活质量的影响:一项横断面研究,估计西班牙人群中效用的下降。

目的下肢骨关节炎(OALL)使与健康相关的生活质量(HRQL)恶化,但是这种影响尚未通过标准化措施量化。我们打算通过基于个人喜好与一般人群的比较来​​评估OALL对HRQL的影响。方法设计了横断面研究。从西班牙普通人群中选出了6234名年龄在50岁以上且没有OALL的受试者(国家健康调查2011-12)。从美国风湿病协会的标准中,从比斯开亚,马德里和特内里费岛的六家医院和21家初级保健中心招募了机会性样本,该样本是根据美国风湿病协会的标准诊断为髋关节(n = 331)或膝部骨关节炎(n = 393)的50岁以上患者。在2015年1月至2015年12月之间。HRQL是用EQ-5D-5L测量的,然后将结果转换为效用分数。考虑了社会人口统计学变量(年龄,性别,社会群体,同居生活),慢性病数量和体重指数。使用西安大略省和麦克马斯特大学的骨关节炎指数以及牛津髋关节评分和牛津膝盖评分来收集OALL的临床阶段。使用效用指数作为因变量来构造广义线性模型。结果OALL患者表达的HRQL显着低于一般人群。在调整了社会人口统计学和临床​​特征后,髋部骨关节炎的平均效用损失为-0.347(95%CI:-0.390,-0.303),膝部骨关节炎的平均效用损失为-0.295(95%CI:-0.336,-0.255) 。在医院接受治疗的OALL患者的效用损失为-0。112(95%CI:-0.158,-0.065)。结论OALL对HRQL有很大影响。与没有骨关节炎的普通人群相比,患有OALL的人的效用损失约为0.3点,这与其他慢性病和一般关节炎的效用损失相比非常高。
更新日期:2020-01-26
down
wechat
bug