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Synthesis of [18F]Fluoroform with High Molar Activity
European Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2020-02-25 , DOI: 10.1002/ejoc.202000056
Anna Pees 1 , Albert D. Windhorst 1 , Maria J. W. D. Vosjan 2 , Vincent Tadino 3 , Danielle J. Vugts 1
Affiliation  

The synthesis of fluorine‐18 labelled fluoroform was optimized towards high molar activities of close to 100 GBq/µmol. This was achieved by implementing a novel radiofluorination reagent, [18F]triflyl fluoride, which allowed 100‐fold reduction of base and cryptand amounts in the radiofluorination reaction.
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中文翻译:

高摩尔活性[18F]氟仿的合成

对氟18标记的氟仿的合成进行了优化,以实现接近100 GBq / µmol的高摩尔活性。这是通过使用一种新型的放射性氟化试剂[ 18 F]三氟甲烷实现的,该试剂可以使放射性氟化反应中的碱和穴状配体数量减少100倍。
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更新日期:2020-02-25
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