The World Health Organization classifies ovarian granulosa cell tumors as sex cord stromal tumors pure sex cord and both, adult granulosa and juvenile granulosa cell tumors are described. Usually, they appear as solid or cystic solid tumors and less commonly the tumors are entirely cystic, which results in scarce literature published on this presentation. Juvenile type presents histologically a lobulated appearance Call-Exner bodies are infrequent, luteinization is common, and it is usual to observe follicles containing eosinophilic or basophilic secretions. Adult type typically shows a proliferation of uniform cells with vesicular nuclei that show typical grooves. It is important to take into account the entirely cystic presentation to avoid wrong diagnoses such as ovarian follicular cyst. From the pathological point of view there are no overwhelming data that could clearly differentiate a cystic granulosa cell tumor from a follicular cyst. However, some authors have described macroscopic and microscopic findings that should be taken into account to perform the differential diagnostic between these entities. Six cystic granulosa cell tumor cases from the period 1973–2017 from our Pathology Department were studied, and they included three adult granulosa cell tumors and three juvenile granulosa cell tumors. We analyzed clinical presentation and histological features like patterns, nuclear atypia, epithelium-stroma relationship, mitotic index, and presence of necrosis in order to establish whether there is a correlation among these parameters and clinical behavior.

中文翻译：

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卵巢颗粒细胞瘤：囊性表现6例

世界卫生组织将卵巢颗粒细胞肿瘤分类为性索间质肿瘤为纯性索，并描述了成年颗粒和青少年颗粒细胞瘤。通常，它们表现为实体或囊性实体瘤，较少见的是肿瘤完全是囊性的，这导致发表在该论文上的文献稀少。幼虫类型在组织学上呈小叶状外观，Call-Exner体很少见，黄体化很常见，通常观察到含有嗜酸性或嗜碱性分泌物的卵泡。成年型通常表现出具有泡状核的均匀细胞的增殖，其具有典型的凹槽。重要的是要考虑整个囊性表现，以避免错误的诊断，例如卵巢滤泡性囊肿。从病理学的观点来看，没有压倒性的数据可以清楚地区分囊性颗粒细胞瘤和滤泡性囊肿。但是，一些作者描述了宏观和微观发现，在进行这些实体之间的差异诊断时应考虑这些发现。研究人员从病理科的1973-2017年期间对6例囊性颗粒细胞瘤病例进​​行了研究，其中包括3例成人颗粒细胞瘤和3例青少年颗粒细胞瘤。我们分析了临床表现和组织学特征，例如模式，核型异型性，上皮-基质关系，有丝分裂指数和坏死的存在，以确定这些参数与临床行为之间是否存在相关性。