A general synthetic strategy is developed to synthesize water soluble receptors by employing tripodal system based on a cyclotriphosphaze platform. The developed model is successfully synthesized and characterized by using elemental analysis, FT-IR, MALDI-TOF, ¹H NMR, ¹³C NMR and ³¹P NMR techniques. The fluorescence sensing performance of prepared water soluble tripodal systems were evaluated by UV/Vis and fluorescence spectroscopies. According to obtained results, two novel water-soluble sensing platforms were selective and sensitive fluorescence receptors for detections of Fe³⁺ and Cu²⁺ ions in both the absence and presence of competitive ions. In addition, the iron receptor also displays biological function, therefore, the cytotoxicity and fluorescence microscopy experiments were applied and it was demonstrated that compound 3 was non-cytotoxic, and can be used as fluorescence imaging sensors for Fe³⁺ in living cells. According to obtained results, proposed synthetic strategy could be applied to develop water soluble receptors for not only iron and/or copper ions but also many different metal ions of interest using a variety of fluoroionophores.

通过采用基于环三磷平台的三脚架系统，开发了一种通用的合成策略来合成水溶性受体。通过元素分析，FT-IR，MALDI-TOF，¹ H NMR，¹³ C NMR和³¹ P NMR技术成功地合成并表征了开发的模型。制备的水溶性三脚架系统的荧光传感性能通过UV / Vis和荧光光谱法进行评估。根据获得的结果，两个新型水溶性传感平台是用于检测Fe ³⁺和Cu ^2+的选择性和灵敏荧光受体。在没有竞争性离子存在和不存在竞争性离子的情况下 另外，铁受体也显示出生物学功能，因此，进行了细胞毒性和荧光显微镜实验，证明了化合物3是无细胞毒性的，并且可以用作活细胞中Fe ^3+的荧光成像传感器。根据获得的结果，提出的合成策略可以应用于开发使用多种氟离子载体的水溶性受体，所述水溶性受体不仅用于铁和/或铜离子，而且用于感兴趣的许多不同金属离子。