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Systematic review and meta-analysis of epidemiological literature evaluating the association between exposure to man-made vitreous fibers and respiratory tract cancers.
Regulatory Toxicology and Pharmacology ( IF 3.4 ) Pub Date : 2020-01-25 , DOI: 10.1016/j.yrtph.2020.104585
Natalie Suder Egnot 1 , Stacey M Benson 1 , Mark F Vater 1 , Rebecca Hazan 2 , Opal Patel 3 , Gary M Marsh 1
Affiliation  

We conducted a systematic review and meta-analysis of epidemiological studies that evaluated occupational exposure to man-made vitreous fibers (MMVF) including glass, rock, and slag wools, and respiratory tract cancers (RTC) including cancers of the larynx, trachea, bronchus, and lung. The MEDLINE/PubMed and Web of Science databases were searched in order to identify epidemiological studies that evaluated the association between occupational MMVF exposure and RTCs. We performed random-effects meta-analyses of relevant studies identified by our literature search, and evaluated sources of between-study heterogeneity. The pooled relative risk (RR) of RTC among workers exposed to MMVFs was 1.09 (95% CI = 0.97, 1.22). The RR was closer to 1.0 when limiting the analysis to effect estimates from studies that accounted for the main a priori risk factors for RTC, asbestos exposure and smoking (RR = 1.03, 95% CI = 0.90, 1.18). Overall, our synthesis of the epidemiological literature suggests that occupational MMVF exposure is not associated with risk of RTC.

中文翻译:

流行病学文献的系统评价和荟萃分析,评估了人造玻璃体纤维暴露与呼吸道癌症之间的关系。

我们对流行病学研究进行了系统的回顾和荟萃分析,评估了职业性接触人造玻璃纤维(MMVF)的机会,包括玻璃,岩石和矿渣羊毛,以及呼吸道癌症(RTC)包括喉癌,气管癌,支气管癌和肺。搜索MEDLINE / PubMed和Web of Science数据库,以识别流行病学研究,以评估职业性MMVF暴露与RTC之间的关联。我们通过文献检索确定了相关研究的随机效应荟萃分析,并评估了研究之间异质性的来源。在接触MMVF的工人中,RTC的汇总相对风险(RR)为1.09(95%CI = 0.97,1.22)。RR接近1。当将分析限制为影响研究的估计值时,该值为0,而这些研究是RTC,石棉暴露和吸烟的主要先验风险因素(RR = 1.03,95%CI = 0.90,1.18)。总体而言,我们对流行病学文献的综合表明,职业性MMVF暴露与RTC风险无关。
更新日期:2020-01-26
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