With the development of biotherapy, biomacromolecular drugs have gained tremendous attention recently, especially in drug development field due to the sophisticated functions in vivo. Over the past few years, a motley variety of drug delivery strategies have been developed for biomacromolecular drugs to overcome the difficulties in the druggability, e.g., the instability and easily restricted by physiologic barriers. The application of novel delivery systems to deliver biomacromolecular drugs can usually prolong the half-life, increase the bioavailability, or improve patient compliance, which greatly improves the efficacy and potentiality for clinical use of biomacromolecular drugs. In this review, recent studies regarding the drug delivery strategies for macromolecular drugs in cancer therapy are summarized, mainly drawing on the development over the last five years.

随着生物疗法的发展，生物大分子药物近来得到了极大的关注，特别是在药物开发领域，由于体内复杂的功能。在过去的几年中，已经为生物大分子药物开发了各种各样的药物递送策略，以克服可药物性方面的困难，例如不稳定，容易受到生理障碍的限制。新颖的递送系统用于递送生物大分子药物的应用通常可以延长半衰期，增加生物利用度或改善患者的依从性，这极大地提高了生物大分子药物在临床上的功效和潜力。在这篇综述中，总结了有关癌症治疗中大分子药物给药策略的最新研究，主要是根据最近五年的发展。