A successful pregnancy requires many physiological adaptations from the mother, including the establishment of tolerance toward the semiallogeneic fetus. Innate lymphoid cells (ILCs) have arisen as important players in immune regulation and tissue homeostasis at mucosal and barrier surfaces. Dimensionality reduction and transcriptomic analysis revealed the presence of two novel CD56Bright decidual ILCs that express low T-bet and divergent Eomes levels. Transcriptional correlation with recently identified first trimester decidual dNKs suggests that these novel decidual ILCs might be present throughout pregnancy. Functional testing with permutation analysis revealed production of multiple factors by individual cells, with a preference for IFNγ and VEGF. Overall, our data suggests continuity of a unique decidual innate lymphocytes across pregnancy with a polyfunctional functional profile conducive for pregnancy.

中文翻译：

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蜕膜先天淋巴细胞的转录和功能编程。

成功怀孕需要母亲做出许多生理适应，包括建立对半同种异体胎儿的耐受性。先天淋巴细胞（ILC）已成为粘膜和屏障表面免疫调节和组织稳态的重要参与者。降维和转录组分析揭示了两种新型 CD56Bright 蜕膜 ILC 的存在，它们表达低 T-bet 和不同的 Eomes 水平。与最近发现的妊娠早期蜕膜 dNK 的转录相关性表明，这些新的蜕膜 ILC 可能存在于整个怀孕期间。排列分析的功能测试揭示了单个细胞产生多种因子，其中偏爱 IFNγ 和 VEGF。全面的，