PURPOSE To describe the optical coherence tomographic findings of hyperreflective foci (HF) in neovascular age-related macular degeneration and evaluate the use of HF to predict visual outcome after antivascular endothelium growth factor (anti-VEGF) therapy. METHODS This was a post-hoc analysis of a retrospective cohort study. Hyperreflective foci were localized in the inner retina, outer retina, or subretinal fluid (SRF) layer. The treatment response of HF was recorded. The association between HF and visual outcome was analyzed. RESULTS We enrolled 126 eyes. Hyperreflective foci involving more than one layer were associated with poor initial visual acuity (P < 0.001). Hyperreflective foci in each layer at baseline were negatively correlated with baseline visual acuity. At 3 months posttreatment, HF in the SRF layer had decreased significantly (P = 0.003), which was faster compared with HF in other layers. Baseline HF status at each layer was not associated with final visual outcome. The eyes with reduced HF in the SRF at 3 months had better visual improvement at 12 months (P = 0.038). CONCLUSION Hyperreflective foci involving multiple layers were associated with poor initial visual acuity but not with final visual outcome. With anti-VEGF treatment, HF in the SRF layer resolved faster, which may predict better visual outcome.

中文翻译：

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高反射灶可预测新血管性年龄相关性黄斑变性中抗血管内皮生长因子的治疗结果。

目的描述高反射灶（HF）在新生血管性年龄相关性黄斑变性中的光学相干断层扫描发现，并评估在预防性血管内皮生长因子（anti-VEGF）治疗后，HF预测视觉结果的用途。方法这是一项回顾性队列研究的事后分析。高反射灶位于视网膜内，视网膜外或视网膜下液（SRF）层。记录HF的治疗反应。分析了HF与视觉结果之间的关联。结果我们登记了126只眼睛。涉及超过一层的高反射灶与较差的初始视力有关（P <0.001）。基线每层的高反射灶与基线视力呈负相关。治疗后3个月，SRF层中的HF显着降低（P = 0.003），比其他层中的HF更快。每层的基线HF状态与最终的视觉结果无关。在3个月时SRF中HF降低的眼睛在12个月时有更好的视觉改善（P = 0.038）。结论涉及多层的高反射灶与较差的初始视力有关，但与最终的视觉结果无关。通过抗VEGF治疗，SRF层中的HF分解速度更快，这可能预示了更好的视觉效果。结论涉及多层的高反射灶与较差的初始视力有关，但与最终的视觉结果无关。通过抗VEGF治疗，SRF层中的HF分解速度更快，这可能预示了更好的视觉效果。结论涉及多层的高反射灶与较差的初始视力有关，但与最终的视觉结果无关。通过抗VEGF治疗，SRF层中的HF分解速度更快，这可能预示了更好的视觉效果。