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Structural dynamics of tween-based microemulsions for antimuscarinic drug mirabegron
Colloid and Polymer Science ( IF 2.4 ) Pub Date : 2020-01-24 , DOI: 10.1007/s00396-020-04603-w
Muhammad Faizan Nazar , Ayesha Mujeed , Muhammad Yasir Siddique , Muddassar Zafar , Muhammad Atif Saleem , Asad Muhammad Khan , Muhammad Ashfaq , Sajjad Hussain Sumrra , Muhammad Zubair , Muhammad Nadeem Zafar

Microemulsions (μEs)-based drug delivery is known to be superior as well as effective due to customizable and easy management, efficiency and capability, and quick drug absorption over a wide range of targets. Herein, two μE formulations were established comprising of clove oil (as oil phase), water (as aqueous phase), Tween-80 (as surfactant), isopropanol, and methanol (as cosurfactant) for formulation A (μE-A) and formulation B (μE-B), respectively, and further used for the encapsulation of an antimuscarinic drug, mirabegron (MBG). Multiple complementary measurements, namely, electrical conductivity ( σ ), viscosity ( η ), and optical microscopy, show the existence of phase transition from W/O to O/W μE via intermediate bicontinuous channels. MBG showed long storage stability as well as good solubility i.e. 3.0 and 2.5 wt% at pH 6.4 in optimum μE-A and μE-B, respectively. Furthermore, no apparent aggregation of MBG was observed, as revealed by scanning transmission electron microscopy and peak correlations of IR analysis, suggesting the stability of MBG inside the formulations. Likewise, fluorescence detection senses the interfacial environment of MBG molecules in the examined formulations that could be vital for understanding the mechanism of controlled drug release. Graphical abstract Structural Dynamics of Tween-Based Microemulsions for Antimuscarinic Drug Mirabegron

中文翻译:

用于抗毒蕈碱药物米拉贝隆的吐温微乳的结构动力学

众所周知,基于微乳液 (μEs) 的药物递送由于可定制且易于管理、效率和能力以及对广泛靶点的快速药物吸收而卓越且有效。在此,建立了两种 μE 制剂,包括丁香油(作为油相)、水(作为水相)、Tween-80(作为表面活性剂)、异丙醇和甲醇(作为辅助表面活性剂)用于制剂 A (μE-A) 和制剂B (μE-B) 分别用于封装抗毒蕈碱药物米拉贝隆 (MBG)。多项互补测量,即电导率 (σ)、粘度 (η) 和光学显微镜,表明存在通过中间双连续通道从 W/O 到 O/W μE 的相变。MBG 显示出长期的储存稳定性以及良好的溶解性,即在 pH 6 时分别为 3.0 和 2.5 重量%。分别在最佳 μE-A 和 μE-B 中为 4。此外,没有观察到明显的 MBG 聚集,如扫描透射电子显微镜和 IR 分析的峰值相关性所揭示的,表明制剂内 MBG 的稳定性。同样,荧光检测可感知受检制剂中 MBG 分子的界面环境,这对于理解药物控释机制至关重要。用于抗毒蕈碱药物米拉贝隆的吐温微乳液的图形抽象结构动力学 荧光检测可感知受检制剂中 MBG 分子的界面环境,这对于理解药物控释机制至关重要。用于抗毒蕈碱药物米拉贝隆的吐温微乳液的图形抽象结构动力学 荧光检测可感知受检制剂中 MBG 分子的界面环境,这对于理解药物控释机制至关重要。用于抗毒蕈碱药物米拉贝隆的吐温微乳液的图形抽象结构动力学
更新日期:2020-01-24
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