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Can phase separation buffer cellular noise?
Science ( IF 41.037 ) Pub Date : 2020-01-24 , DOI: 10.1126/science.aba0446
Joshua A. Riback, Clifford P. Brangwynne

Scientists have long marveled at the ability of complex patterns to emerge from seemingly chaotic origins. In biology, each cell must circumvent the stochastic nature, or noise, inherent to chemical reactions and molecular diffusion. This noise introduces large fluctuations in messenger RNA (mRNA) and protein concentrations, which might be deleterious to processes such as biosynthesis, macroscale organization, and self-replication. Noise may be decreased through compartmentalization, including liquid-liquid phase separation (LLPS), a process underlying the formation of membraneless compartments (1, 2). On page 464 of this issue, Klosin et al. (3) provide evidence that LLPS can buffer noise in cells and may play a role in stabilizing various biological circuits.
更新日期:2020-01-24

 

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