Glial cells in the brain use neuropeptides to communicate stress responses and longevity Aging is a multifaceted process that results in organismal decay. At the cellular level, protein homeostasis is a key system that becomes dysregulated with age, causing the accumulation of aberrant or unfolded proteins. In a youthful individual, unfolded proteins normally trigger the unfolded protein response (UPR), which upregulates the protein clearance machinery and returns cells to a homeostatic state. The UPR is typically induced in a cell-autonomous manner. But some cells communicate protein folding stress to distal cells. For example, neurons communicate activation of the UPR to peripheral tissues to promote longevity in the worm Caenorhabditis elegans (1). On page 436 of this issue, Frakes et al. (2) show that support cells in the brain called glial cells (3) can also initiate long-range activation of the endoplasmic reticulum UPR (UPRER) in distal cells to coordinate stress resistance and longevity in C. elegans and that this occurs through neuropeptide secretion.

中文翻译：

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支持大脑中的细胞促进长寿

大脑中的神经胶质细胞使用神经肽来传达压力反应和长寿 衰老是一个多方面的过程，会导致机体腐烂。在细胞水平上，蛋白质稳态是一个关键系统，随着年龄的增长而失调，导致异常或未折叠蛋白质的积累。在一个年轻的个体中，未折叠蛋白通常会触发未折叠蛋白反应 (UPR)，这会上调蛋白清除机制并使细胞恢复到稳态。UPR 通常以细胞自主方式诱导。但是一些细胞将蛋白质折叠应力传递给远端细胞。例如，神经元将 UPR 的激活传递给外周组织，以促进秀丽隐杆线虫 (Caenorhabditis elegans) 的长寿 (1)。在本期第 436 页上，Frakes 等人。