Despite extensive evidence showing that exposure to specific chemicals can lead to disease, current research approaches and regulatory policies fail to address the chemical complexity of our world. To safeguard current and future generations from the increasing number of chemicals polluting our environment, a systematic and agnostic approach is needed. The “exposome” concept strives to capture the diversity and range of exposures to synthetic chemicals, dietary constituents, psychosocial stressors, and physical factors, as well as their corresponding biological responses. Technological advances such as high-resolution mass spectrometry and network science have allowed us to take the first steps toward a comprehensive assessment of the exposome. Given the increased recognition of the dominant role that nongenetic factors play in disease, an effort to characterize the exposome at a scale comparable to that of the human genome is warranted.

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暴露组与健康：化学与生物学相遇的地方

尽管大量证据表明接触特定化学品会导致疾病，但当前的研究方法和监管政策未能解决我们世界的化学复杂性。为了保护当代和后代免受越来越多的化学品污染我们的环境，需要一种系统的和不可知的方法。“暴露组”概念力求捕捉合成化学品、膳食成分、心理社会压力源和物理因素的多样性和暴露范围，以及它们相应的生物反应。高分辨率质谱和网络科学等技术进步使我们能够迈出全面评估暴露体的第一步。鉴于人们越来越认识到非遗传因素在疾病中的主导作用，