Urolithin A (UA) is a gut‐derived bacterial metabolite from ellagic acid found in pomegranates, berries, and nuts can downregulate cell proliferation and migration. Cell proliferation and cell motility require actin reorganization, which is under control of ras‐related C3 botulinum toxin substrate 1 (Rac1) and p21 protein‐activated kinase 1 (PAK1). The present study explores whether UA can modify actin cytoskeleton in cancer cells.

中文翻译：

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肠细菌代谢产物尿石蛋白A降低了肌动蛋白在癌细胞中的聚合和迁移。

尿石素A（UA）是从石榴，浆果和坚果中发现的鞣花酸中的肠源性细菌代谢产物，可下调细胞增殖和迁移。细胞增殖和细胞运动需要肌动蛋白重组，这受ras相关的C3肉毒杆菌毒素底物1（Rac1）和p21蛋白激活的激酶1（PAK1）的控制。本研究探讨了UA是否可以修饰癌细胞中的肌动蛋白细胞骨架。