Lipids are considered to be critical contributors to nutrition, structural function, metabolic function, and other biological roles. They vary from one biological source to another. Here, the lipids from three common sources (soybean, egg yolk, and shrimp head) were comprehensively compared and characterized using the lipidomics approach, together with the UPLC-Q-Exactive Orbitrap/MS method. A total of 3027 lipid structures containing 778 fatty acids, 750 glycerolipids, 1283 glycerophospholipids, 200 sphingolipids, and 16 sterol lipids were first identified and quantified in these resources. The characteristic lipid species with significant differences among groups were determined by lipidomics analysis. Besides, the antithrombotic, antioxidant, and anti-inflammatory activities were evaluated based on the zebrafish model. The correlation between differential lipids and activities was also analyzed. Our comprehensive lipidomics profiling and bioactivities of lipids from different sources in vivo can provide evidence for their future applications.

中文翻译：

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UPLC-Q-Exactive Orbitrap / MS方法对不同物质来源的脂质指纹图谱及其基于斑马鱼的活性比较。

脂质被认为是营养，结构功能，代谢功能和其他生物学作用的关键因素。它们从一种生物来源到另一种生物来源都不同。在此，使用脂质组学方法以及UPLC-Q-Exactive Orbitrap / MS方法对三种常见来源（大豆，蛋黄和虾头）的脂质进行了全面比较和表征。在这些资源中，首先鉴定并定量了总共3027个脂质结构，其中包含778个脂肪酸，750个甘油脂，1283个甘油磷脂，200个鞘脂和16种甾醇脂质。通过脂质组学分析确定组之间具有显着差异的特征脂质种类。此外，基于斑马鱼模型评估了抗血栓形成，抗氧化剂和抗炎活性。还分析了差异脂质与活性之间的相关性。我们全面的脂质组学分析和体内不同来源脂质的生物活性可以为它们的未来应用提供证据。