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Optimized skin optical clearing for optical coherence tomography monitoring of encapsulated drug delivery through the hair follicles.
Journal of Biophotonics ( IF 2.8 ) Pub Date : 2020-02-03 , DOI: 10.1002/jbio.201960020
Sergey M Zaytsev 1 , Yulia I Svenskaya 1 , Ekaterina V Lengert 1 , Georgy S Terentyuk 1 , Alexey N Bashkatov 1 , Valery V Tuchin 1 , Elina A Genina 1
Affiliation  

Hair follicles (HF) represent a drug delivery reservoir for improved treatment of skin disorders. Although various particulate systems play an important role in HF‐targeting, their optical monitoring in skin is challenging due to strong light scattering. Optical clearing is an effective approach allowing the increasing of particle detection depth in skin. The enhancement of optical probing depth (OPD) and optical detection depth (ODD) of particle localization using optical coherence tomography (OCT) was evaluated under application of various optical clearing agents (OCAs) together with skin permeability enhancers ex vivo in rats. Efficient OPD increasing was demonstrated for all investigated OCAs. However, skin dehydration under action of hyperosmotic agents led to the worsening of OCT‐contrast in dermis decreasing the ODD. Lipophilic agents provided optical clearing of epidermis without its dehydration. The highest ODD was obtained at application of a PEG‐400/oleic acid mixture. This OCA was tested in vivo showing beneficial ODD and OPD enhancement.image

中文翻译:

优化的皮肤光学清洁功能,用于通过光学相干断层扫描技术监视通过毛囊进行的封装药物输送。

毛囊(HF)代表药物输送库,用于改善皮肤疾病的治疗。尽管各种微粒系统在HF靶向中发挥着重要作用,但是由于强烈的光散射,它们在皮肤中的光学监控仍具有挑战性。光学清除是允许增加皮肤中颗粒检测深度的有效方法。在大鼠体内使用各种光学清除剂(OCA)和皮肤通透性增强剂的情况下,评估了使用光学相干断层扫描(OCT)增强的颗粒定位的光学探测深度(OPD)和光学检测深度(ODD)。对所有调查的OCA均显示出有效的OPD增加。但是,在高渗剂的作用下皮肤脱水会导致真皮中的OCT对比恶化,从而降低ODD。亲脂性试剂提供了表皮的光学清除,而没有脱水。使用PEG-400 /油酸混合物可获得最高的ODD。该OCA已经过测试体内显示有益的ODD和OPD增强。图片
更新日期:2020-02-03
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