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Circulating tumor cells in cancer patients: developments and clinical applications for immunotherapy.
Molecular Cancer ( IF 37.3 ) Pub Date : 2020-01-24 , DOI: 10.1186/s12943-020-1141-9
Xiaoming Zhong 1, 2 , Hangtian Zhang 2 , Ying Zhu 3 , Yuqing Liang 4 , Zhuolin Yuan 2 , Jiachen Li 2 , Jing Li 2 , Xin Li 2 , Yifan Jia 2 , Tian He 2 , Jiangyuan Zhu 2 , Yu Sun 1 , Wengting Jiang 1 , Hui Zhang 5 , Cheng Wang 6 , Zunfu Ke 1, 5
Affiliation  

Cancer metastasis is the leading cause of cancer-related death. Circulating tumor cells (CTCs) are shed into the bloodstream from either primary or metastatic tumors during an intermediate stage of metastasis. In recent years, immunotherapy has also become an important focus of cancer research. Thus, to study the relationship between CTCs and immunotherapy is extremely necessary and valuable to improve the treatment of cancer. In this review, based on the advancements of CTC isolation technologies, we mainly discuss the clinical applications of CTCs in cancer immunotherapy and the related immune mechanisms of CTC formation. In order to fully understand CTC formation, sufficiently and completely understood molecular mechanism based on the different immune cells is critical. This understanding is a promising avenue for the development of effective immunotherapeutic strategies targeting CTCs.

中文翻译:

癌症患者中的循环肿瘤细胞:免疫疗法的发展和临床应用。

癌症转移是癌症相关死亡的主要原因。在转移的中间阶段,循环肿瘤细胞(CTC)从原发性或转移性肿瘤脱落进入血液。近年来,免疫疗法也已成为癌症研究的重要重点。因此,研究CTC与免疫疗法之间的关系对于改善癌症的治疗极为必要且有价值。本文基于CTC分离技术的发展,主要探讨CTC在癌症免疫治疗中的临床应用以及相关的CTC形成的免疫机制。为了充分了解CTC的形成,充分和完全了解基于不同免疫细胞的分子机制至关重要。
更新日期:2020-01-24
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