Enduring sleep loss is a risk factor for a variety of both somatic and mental health issues. When subjected to sleep loss, the brain becomes vulnerable to critical alterations in cognitive and emotional processing. In our study, we examined the effect of psychosocial stress on amygdala resting-state functional connectivity in participants with cumulative sleep loss calculated across the seven days preceding scanning. For this purpose, forty-five healthy male participants completed a one-week sleep diary and underwent resting-state scans before and after taking part in the ScanSTRESS paradigm, which allows social stress induction during functional magnetic resonance imaging. Sleep loss was negatively associated with seed-based functional connectivity of the left amygdala with the medial prefrontal cortex, dorsal anterior cingulate cortex, anterior insula, posterior cingulate cortex, and dorsolateral prefrontal cortex. That is, participants with higher amounts of sleep loss showed reduced left amygdala connectivity after social stress induction to cortical regions encompassing main nodes of the brain's default mode network and salience network. Our results shed more light on how brain functional connectivity may shape the brain's stress response in the context of naturally occurring sleep loss, revealing a potential neural mechanism for increased vulnerability to stress-related psychopathology.

中文翻译：

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社会心理压力后自然发生的睡眠不足与杏仁核静息状态功能连接减少的关联

长期失眠是导致各种躯体和心理健康问题的危险因素。当遭受睡眠不足时，大脑变得容易受到认知和情绪处理的关键变化的影响。在我们的研究中，我们研究了心理社会压力对扫描前 7 天内累积睡眠不足的参与者的杏仁核静息状态功能连接的影响。为此，45 名健康男性参与者完成了为期一周的睡眠日记，并在参与 ScanSTRESS 范式之前和之后进行了静息状态扫描，这允许在功能磁共振成像期间感应社会压力。睡眠不足与左杏仁核与内侧前额叶皮层、背侧前扣带回皮层的基于种子的功能连接呈负相关。前岛叶、后扣带皮层和背外侧前额叶皮层。也就是说，在社会压力诱导到包括大脑默认模式网络和显着性网络主要节点的皮层区域后，睡眠不足的参与者表现出左侧杏仁核连接性降低。我们的研究结果进一步阐明了大脑功能连接如何在自然发生的睡眠不足的情况下塑造大脑的压力反应，揭示了一种潜在的神经机制，可以增加对压力相关精神病理学的脆弱性。s 默认模式网络和显着网络。我们的研究结果进一步阐明了大脑功能连接如何在自然发生的睡眠不足的情况下塑造大脑的压力反应，揭示了一种潜在的神经机制，可以增加对压力相关精神病理学的脆弱性。s 默认模式网络和显着网络。我们的研究结果进一步阐明了大脑功能连接如何在自然发生的睡眠不足的情况下塑造大脑的压力反应，揭示了一种潜在的神经机制，可以增加对压力相关精神病理学的脆弱性。