Eight previously undescribed naturally-occurring compounds, including abyssomycins Y - Z, methyl aeruginoate, desferri-ferrithocin-4-hydroxyphenethylester, streptomethiocins A - B, furaquinocin I, and streptolactone, along with eleven known compounds were isolated from the endophytic Streptomyces sp. TBRC7642. The chemical structures were determined based on spectroscopic means including 1D, 2D NMR spectroscopy and mass spectrometry. The absolute configurations were assigned by relying on CD spectra and their optical rotations. In addition, the isolated compounds were evaluated for biological activity, such as antimalarial, antitubercular, antibacterial (both Gram-positive and Gram-negative bacteria), as well as for cytotoxicity against MCF-7, NCI-H187, and Vero cells.

中文翻译：

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来自内生链霉菌属的抗菌、抗结核、抗疟和细胞毒性物质。TBRC7642

八种以前未描述的天然存在的化合物，包括深霉素 Y-Z、绿脓酸甲酯、去铁-铁蛋白-4-羟基苯乙酯、链甲硫菌素 A-B、呋喃喹啉 I 和链内酯，以及 11 种已知化合物从内生链霉菌属中分离出来。TBRC7642。基于光谱方法确定化学结构，包括一维、二维核磁共振光谱和质谱。绝对构型是根据 CD 光谱及其旋光度分配的。此外，还评估了分离的化合物的生物活性，例如抗疟、抗结核、抗菌（革兰氏阳性和革兰氏阴性细菌），以及对 MCF-7、NCI-H187 和 Vero 细胞的细胞毒性。