In the last 50 years, our vision of the cerebellum has vastly evolved starting with Voogd's (1967) description of extracerebellar projections' terminations and how the projection maps transformed the presumptive homogeneity of the cerebellar cortex into a more complex center subdivided into transverse and longitudinal distinct functional zones. The picture became still more complex with Richard Hawkes and colleagues' (Gravel et al., 1987) discovery of the biochemical heterogeneity of Purkinje cells (PCs), by screening their molecular identities with monoclonal antibodies. Antigens were expressed in a parasagittal pattern with subsets of PCs either possessing or lacking the respective antigens, which divided the cerebellar cortex into precise longitudinal compartments that are congruent with the projection maps. The correlation of these two maps in adult cerebellum shows a perfect matching of developmental mechanisms. This review discusses a series of arguments in favor of the essential role played by PCs in organizing the microzonation of the cerebellum during development (the "matching" hypothesis).

中文翻译：

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小脑微区划所涉及的细胞机制。

在过去的50年中，从Voogd（1967）对小脑外投影的终止以及投影图如何将小脑皮层的假定同质性转变为更复杂的中心（分为横向和纵向的不同点）开始，我们对小脑的认识已发生了巨大的变化。功能区。理查德·霍克斯（Richard Hawkes）及其同事（Gravel等，1987）通过用单克隆抗体筛查浦肯野细胞（PC）的分子同一性，发现了浦肯野细胞（PC）的生化异质性，使情况变得更加复杂。抗原以旁矢状面表达，PC子集具有或不具有各自的抗原，从而将小脑皮层分成与投影图一致的精确纵向区室。这两幅图在成年小脑中的相关性显示出发育机制的完美匹配。这篇评论讨论了一系列论证，这些论据支持PC在发育过程中组织小脑微区带中发挥的重要作用（“匹配”假设）。